TARC Activators
TARC Activators are a class of chemicals that enhance the functional activity of TARC, a chemokine involved in the trafficking of T cells to inflammatory sites. These activators exert their effects by influencing the biochemical pathways that directly regulate the activity of TARC. Forskolin, Isoprenaline, Rolipram, PGE2, IBMX, Epinephrine, Dobutamine, Salbutamol, Terbutaline, Bucladesine, and Adenosine all increase intracellular cAMP levels, leading to enhanced TARC activity. This is consistent with the established role of cAMP-dependent pathways in the regulation of TARC activity. These compounds either activate adenylate cyclase, leading to increased cAMP production (Forskolin, Isoprenaline, Epinephrine, Dobutamine, Salbutamol, Terbutaline, Adenosine), or inhibit phosphodiesterase, preventing the breakdown of cAMP (Rolipram, IBMX). PGE2 works through its EP2 and EP4 receptors to elevate cAMP levels, while Bucladesine is a cell-permeable cAMP analog that directly increases cAMP availabilityIn contrast, H-89, a potent inhibitor of protein kinase A (PKA), enhances TARC activity by influencing the cAMP/PKA/CREB pathway. PKA phosphorylates and activates the cAMP response element-binding protein (CREB), which is a crucial player in the regulation of TARC. The inhibition of PKA by H-89 can thus potentiate TARC activity by altering the dynamics of this pathway.
These compounds do not enhance TARC transcription or translation but act by influencing the biochemical pathways that regulate TARC activity. The specificity of these compounds in their action provides a clear example of how the modulation of biochemical pathways can be harnessed to enhance the activity of specific proteins. The understanding of these mechanisms not only enriches our knowledge of protein regulation but also opens up new avenues for the exploration of protein function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a potent activator of adenylate cyclase, leading to increased levels of cAMP. As TARC/CCL17 is known to be regulated by cAMP-dependent pathways, the increase in cAMP can enhance the functional activity of TARC. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoprenaline is a β-adrenoceptor agonist that can increase the intracellular levels of cAMP. The increased cAMP can enhance the functional activity of TARC, considering its regulation by cAMP-dependent pathways. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective phosphodiesterase 4 (PDE4) inhibitor that can increase intracellular cAMP levels. Since TARC is known to be regulated by cAMP-dependent pathways, the increase in cAMP can enhance the functional activity of TARC. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) is a lipid compound that can increase cAMP levels through activation of its EP2 and EP4 receptors. The increased cAMP can enhance the functional activity of TARC, as TARC is regulated by cAMP-dependent pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterase (PDE), leading to increased intracellular cAMP levels. As TARC is regulated by cAMP-dependent pathways, increased cAMP can enhance the functional activity of TARC. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine is a hormone and neurotransmitter that can increase intracellular cAMP levels via activation of β-adrenoceptors. The increased cAMP can enhance the functional activity of TARC, given its regulation by cAMP-dependent pathways. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine is a β1-adrenoceptor agonist that can increase intracellular cAMP levels. The increased cAMP can enhance the functional activity of TARC, as TARC is regulated by cAMP-dependent pathways. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol is a β2-adrenoceptor agonist that can increase intracellular cAMP levels. The increased cAMP can enhance the functional activity of TARC, given its regulation by cAMP-dependent pathways. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
Also called Bucladesine, this compound is a cell-permeable cAMP analog. The increased levels of cAMP can enhance the functional activity of TARC, as TARC is regulated by cAMP-dependent pathways. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine is a purine nucleoside that can increase cAMP levels through activation of its A2A and A2B receptors. The increased cAMP can enhance the functional activity of TARC, given its regulation by cAMP-dependent pathways. | ||||||