TARC Antibody (AB98): sc-80339

TARC Antibody (AB98) is a mouse monoclonal IgG1 kappa light chain antibody that detects TARC protein of human origin by western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-TARC antibody (AB98) is available as the non-conjugated format. TARC, or thymus and activation-regulated chemokine, plays a crucial role in the immune system by facilitating T cell migration to sites of inflammation and infection. TARC monoclonal antibody (AB98) recognizes a chemokine primarily expressed in the thymus and spleen, where TARC is involved in regulating T helper type 2 polarized cells through interaction with C-C chemokine receptor CCR4. TARC guides lymphocytes in distinguishing between systemic and intestinal immune responses, thereby influencing the overall immune landscape. TARC′s interaction with CCR4 is vital for recognition of skin vasculature by circulating T cells, essential for effective immune surveillance and response. TARC′s ability to direct immune cells to specific tissues underscores TARC′s significance in both normal immune function and in the pathogenesis of various inflammatory conditions.

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TARC Antibody (AB98) References:

1. Effects of CC, CXC, C, and CX3C chemokines on proliferation of myeloid progenitor cells, and insights into SDF-1-induced chemotaxis of progenitors.  |  Broxmeyer, HE., et al. 1999. Ann N Y Acad Sci. 872: 142-62; discussion 163. PMID: 10372118
2. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.  |  Campbell, JJ., et al. 1999. Nature. 400: 776-80. PMID: 10466728
3. Macrophage-derived chemokine production by activated human T cells in vitro and in vivo: preferential association with the production of type 2 cytokines.  |  Galli, G., et al. 2000. Eur J Immunol. 30: 204-10. PMID: 10602042
4. Pivotal role of the CC chemokine, macrophage-derived chemokine, in the innate immune response.  |  Matsukawa, A., et al. 2000. J Immunol. 164: 5362-8. PMID: 10799899
5. A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock.  |  Chvatchko, Y., et al. 2000. J Exp Med. 191: 1755-64. PMID: 10811868
6. The biological environment of Hodgkin's lymphoma and the role of the chemokine CCL17/TARC.  |  Hnátková, M., et al. 2009. Prague Med Rep. 110: 35-41. PMID: 19591376
7. Biology and Clinical Applicability of Plasma Thymus and Activation-Regulated Chemokine (TARC) in Classical Hodgkin Lymphoma.  |  Zijtregtop, EAM., et al. 2021. Cancers (Basel). 13: PMID: 33672548
8. Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells.  |  Lee, H., et al. 2021. Int J Mol Sci. 22: PMID: 34208434
9. Skin TARC/CCL17 increase precedes the development of childhood atopic dermatitis.  |  Halling, AS., et al. 2023. J Allergy Clin Immunol. 151: 1550-1557.e6. PMID: 36572354
10. CCL17/TARC in autoimmunity and inflammation-not just a T-cell chemokine.  |  Lupancu, TJ., et al. 2023. Immunol Cell Biol. 101: 600-609. PMID: 36975092
11. Elevated serum TARC levels precede classic Hodgkin lymphoma diagnosis by several years.  |  Diepstra, A., et al. 2023. Blood. 142: 1928-1931. PMID: 37748137
12. Differential dynamics of TARC during JAK-inhibitor therapy compared to biological therapies targeting type 2 inflammation.  |  Boesjes, CM., et al. 2024. Clin Exp Allergy. 54: 294-296. PMID: 38158774

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TARC Antibody (AB98) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-TARC Antibody (AB98) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TARC Antibody (AB98) Specifications

Alternate Product Name: TARC

Product Clone Name: AB98

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: TARC

Epitope Species: human

Product Reactivity/Detection: TARC

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for TARC Antibody (AB98): N/A