Taok3 Activators
TAOK3 activators encompass a diverse range of chemical compounds that can influence the activity of Thousand And One Amino Acid Kinase 3 (TAOK3), a protein kinase that plays a significant role in various signaling pathways. These activators are characterized by their ability to modulate the cellular signaling processes in which TAOK3 is involved, such as the MAPK/JNK pathway, cell cycle regulation, and stress response pathways. The chemical classes of these compounds are varied, including kinase inhibitors, enzyme activators, and agents that induce cellular stress or modulate epigenetic status.
The activation of TAOK3 by these compounds typically occurs through indirect mechanisms, whereby the compounds initiate a cascade of events within the cell that leads to the activation of TAOK3. For instance, some compounds can alter the phosphorylation status of kinases that are upstream or downstream of TAOK3, thereby affecting its activity. Other activators may change the concentration of intracellular second messengers, such as cAMP, which in turn can influence TAOK3 activity. Additionally, certain compounds can cause changes in gene expression that result in the upregulation of TAOK3 or related proteins. The compounds can also impact the protein stability and localization of TAOK3, further modulating its function. The common thread among these mechanisms is the alteration of the cellular environment in a manner that promotes the activation of TAOK3, which is central to the signaling pathways that govern cell function and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor known to activate the MAPK/JNK pathway, which could possibly activate TAOK3 as a downstream effect. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of JNK, and by inhibiting one of the downstream targets of TAOK3, it could possibly lead to a compensatory increase in TAOK3 activity as a feedback mechanism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase resulting in increased levels of cAMP, which could possibly modulate various signaling pathways including those involving TAOK3. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that could possibly cause epigenetic changes, potentially affecting the expression levels of various kinases including TAOK3. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can affect cell cycle progression, which could possibly influence TAOK3 activity due to its role in cell cycle regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK, a kinase upstream of ERK in the MAPK pathway, and could possibly cause an adaptive increase in TAOK3 activity as part of the pathway's regulatory feedback. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor, and its inhibition could possibly lead to altered signaling through the MAPK pathways, potentially affecting TAOK3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and by influencing the PI3K/Akt pathway, it could possibly affect intersecting signaling pathways with TAOK3. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin causes ER stress and affects calcium signaling, which could possibly influence TAOK3 activity through stress response pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, affecting many signaling pathways, which could possibly be associated with TAOK3 activity. | ||||||