TAF II p28 Activators
TAF II p28, also known as TAF12, is a protein encoded by the TAF12 gene in humans. The protein is a component of the TFIID complex, a multi-subunit entity that plays a central role in the process of transcription, which is the first step in gene expression.Transcription factors like TFIID are crucial for the initiation of transcription by RNA polymerase II, an enzyme that synthesizes messenger RNA in cells. TAF12, along with other TAFs (TBP-associated factors), helps the TFIID complex to recognize and bind to core promoter regions of genes, thereby facilitating the assembly of the transcription machinery on the DNA.
The TAF II p28 protein is unique in that it possesses two histone fold motifs, which are structural domains that allow TAF12 to interact with other proteins in a manner similar to histone-histone interactions in the nucleosome. These interactions help to stabilize the TFIID complex and may contribute to its function in transcription.Alterations in the function of TAF12 and other TFIID components can have significant effects on gene expression, potentially leading to various diseases. For instance, mutations in TAF12 and other TAF genes have been associated with neurodevelopmental disorders and cancer.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Another histone deacetylase inhibitor, potentially influencing TAF II p28/TAF9 activity. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
A non-nucleoside DNA methyltransferase inhibitor, potentially affecting TAF II p28/TAF9 function. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
A BET bromodomain inhibitor, potentially influencing TAF II p28/TAF9 activity indirectly by modulating transcription regulation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Known to affect multiple cellular processes, could indirectly influence TAF II p28/TAF9 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A compound from turmeric that impacts various cellular processes, including transcriptional regulation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in gene transcription and differentiation, could indirectly affect TAF II p28/TAF9. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
An inhibitor of histone acetyltransferases, potentially influencing TAF II p28/TAF9 function. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $64.00 $183.00 | 11 | |
A histone deacetylase inhibitor, might have indirect effects on TAF II p28/TAF9 activity. | ||||||