TACC2 Activators
TACC2 Activators belong to a specific chemical class that plays a pivotal role in the regulation of various cellular processes. These compounds are characterized by their ability to modulate the activity of TACC2 (Transforming Acidic Coiled-Coil Containing Protein 2), a critical protein involved in mitotic spindle assembly and cell division. TACC2, a member of the TACC family, is known for its importance in microtubule dynamics and cytoskeletal organization during cell division. TACC2 Activators are small molecules or chemical agents that interact with TACC2, resulting in the stimulation or enhancement of its function within the cell.
The primary function of TACC2 Activators is to promote the proper assembly and stability of microtubules during mitosis. Microtubules are dynamic structural components of the cell's cytoskeleton that are essential for processes such as chromosome segregation, cell motility, and intracellular transport. TACC2, when activated by these specific compounds, assists in the regulation of microtubule dynamics, ensuring accurate chromosome alignment and separation during cell division. This intricate control over microtubule dynamics is crucial for maintaining genomic stability and stopping errors in cell division, which can lead to various diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which activates protein kinase A (PKA). PKA can phosphorylate various downstream targets that may include regulatory proteins involved in cell cycle control, potentially enhancing the microtubule-stabilizing function of TACC2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which leads to increased phosphorylation of cellular proteins. By inhibiting PP1/PP2A, the phosphorylation state of proteins involved in microtubule assembly and stability, potentially including TACC2, is increased, enhancing their activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules by binding to β-tubulin and promoting polymerization. This stabilization can enhance the microtubule-associated function of TACC2, which is involved in maintaining spindle integrity during cell division. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits PP1 and PP2A, like okadaic acid, leading to increased phosphorylation of proteins that associate with microtubules. This can indirectly enhance the function of TACC2 in microtubule stabilization and spindle assembly. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor that may indirectly enhance TACC2's role in chromosome alignment and segregation by altering the phosphorylation state of proteins involved in mitotic spindle function and dynamics. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI-2536 is a Plk1 inhibitor. Inhibition of Plk1 can lead to changes in the phosphorylation state of proteins involved in spindle assembly and microtubule dynamics, potentially improving the stabilizing function of TACC2 on microtubules. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
S-Trityl-L-cysteine is a kinesin Eg5 inhibitor, leading to spindle assembly checkpoint activation which may increase the need for TACC2's function in stabilizing microtubules and maintaining spindle integrity. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine disrupts microtubule assembly by binding to tubulin. This disruption can cause cellular mechanisms to upregulate compensatory pathways for microtubule stabilization, potentially enhancing TACC2's functional role. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that activates the spindle assembly checkpoint. The cellular response to nocodazole treatment may involve the upregulation of microtubule-stabilizing proteins like TACC2. | ||||||