TAAR7A Inhibitors
TAAR7A inhibitors are a class of chemical compounds that specifically target and inhibit the function of the trace amine-associated receptor 7A (TAAR7A), a member of the TAAR family, which belongs to the broader class of G-protein coupled receptors (GPCRs). TAAR7A, like other TAAR receptors, is involved in sensing trace amines-biogenic amines present at very low concentrations in the brain and other tissues. These receptors respond to naturally occurring trace amines, triggering intracellular signaling pathways that are crucial for various physiological processes. Inhibitors of TAAR7A act by binding to the receptor and preventing its activation by endogenous ligands, thereby modulating the receptor's ability to transmit signals inside the cell. This inhibition can alter the receptor's interaction with G-proteins and downstream signaling molecules, affecting intracellular responses such as changes in cyclic AMP (cAMP) levels or calcium ion fluxes.
The chemical structure of TAAR7A inhibitors can vary significantly, as they include a range of small molecules and other compounds that are capable of interacting with the receptor in different ways. Some inhibitors may act as competitive antagonists, directly blocking the receptor's active site and preventing trace amines from binding, while others may function as allosteric inhibitors, binding to different parts of the receptor and changing its shape or dynamics, thereby reducing its activity. The inhibition of TAAR7A impacts signal transduction pathways commonly associated with GPCRs, leading to changes in cellular responses. Studying TAAR7A inhibitors allows for a deeper understanding of the role that trace amines and their receptors play in physiological systems. These inhibitors also offer insight into the specific molecular interactions that occur within the receptor and contribute to broader patterns of trace amine signaling, shedding light on the functional diversity within the TAAR receptor family.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may inhibit the expression of trace amine-associated receptor 7A by interfering with transcription factors and downregulating gene expression. Its anti-inflammatory properties might impact signaling pathways involved in the expression of this protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol's ability to modulate transcription factors and inhibit gene expression could lead to the downregulation of trace amine-associated receptor 7A. Its antioxidant properties may also contribute to reducing the expression of this protein. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can potentially inhibit the expression of trace amine-associated receptor 7A by modulating various signaling pathways involved in gene expression regulation. Its antioxidant properties may also contribute to reducing the expression of this protein. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin's modulation of signaling pathways and inhibition of transcription factors might result in the downregulation of trace amine-associated receptor 7A expression. Additionally, its antioxidant properties could play a role in reducing the expression of this protein. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine's interference with transcription factors and modulation of gene expression may lead to the inhibition of trace amine-associated receptor 7A expression. Its anti-inflammatory effects might also impact relevant signaling pathways involved in the expression of this protein. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein's ability to modulate transcription factors and signaling pathways involved in gene expression could result in the downregulation of trace amine-associated receptor 7A. Additionally, its anti-inflammatory properties may influence the expression of this protein. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin's modulation of gene expression through various signaling pathways may inhibit the expression of trace amine-associated receptor 7A. Its anti-inflammatory effects might also contribute to reducing the expression of this protein by impacting relevant pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane may inhibit the expression of trace amine-associated receptor 7A by modulating gene expression through epigenetic mechanisms and inhibiting transcription factors. Its anti-inflammatory properties could also impact signaling pathways involved in the expression of this protein. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin's interference with transcription factors and modulation of signaling pathways may lead to the inhibition of trace amine-associated receptor 7A expression. Additionally, its anti-inflammatory effects could influence relevant pathways involved in the expression of this protein. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin's modulation of signaling pathways and inhibition of transcription factors might result in the downregulation of trace amine-associated receptor 7A expression. Additionally, its antioxidant properties could contribute to reducing the expression of this protein. | ||||||