T3JAM Activators
T3JAM Activators comprise a spectrum of chemical entities that indirectly potentiate the activity of T3JAM by modulating various cellular signaling pathways. Compounds like Forskolin and Epigallocatechin gallate (EGCG) elevate the functionality of T3JAM through different mechanisms; Forskolin enhances cAMP levels, which activates PKA, a kinase likely to phosphorylate T3JAM, thereby boosting its activity in cell adhesion. EGCG, on the other hand, inhibits competitive kinases, reducing phosphorylation events that might otherwise suppress T3JAM's activity, thereby indirectly supporting its role in cellular signaling. LY294002 and U0126, through their inhibitory effects on the PI3K/AKT and MEK1/2 pathways respectively, lower the activity of competing pathways, which could result in an indirect upregulation of T3JAM signaling. Similarly, Sphingosine-1-phosphate, by activating its receptors, might enhance T3JAM's activity via signaling cross-talk, emphasizing the intricate web of cellular communications that facilitate T3JAM activation.
Furthermore, the activity of T3JAM is influenced by changes in intracellular calcium levels induced by compounds like Ionomycin, Thapsigargin, and A23187, which either serve as calcium ionophores or disrupt calcium homeostasis, thereby triggering downstream kinases that may enhance T3JAM function. Staurosporine, despite its broad kinase inhibition profile, might selectively augment T3JAM activity by inhibiting specific kinases that negatively regulate T3JAM. Genistein, through its tyrosine kinase inhibition, could relieve T3JAM from tyrosine kinase-mediated suppression, indirectly promoting its function. Lastly, SB203580, a p38 MAPK inhibitor, could shift the balance of cellular signaling towards pathways that elevate T3JAM's role in the cell. Collectively, these activators reveal a complex network of pathways that, when modulated, can lead to the enhanced activity of T3JAM, underscoring the intricate nature of intracellular signaling dynamics.
SEE ALSO...
Items 1 to 10 of 16 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate T3JAM, leading to its enhanced functional activity within cell-cell adhesion processes. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to an increase in intracellular cAMP levels. This increase can enhance T3JAM function by activating PKA, which may phosphorylate T3JAM or its associated proteins, influencing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate inhibits specific kinases that can phosphorylate T3JAM. This inhibition may reduce competitive signaling, indirectly enhancing T3JAM's functional role in cellular processes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, causing an increase in intracellular levels of cAMP and cGMP. This elevation indirectly promotes the activation of PKA and could enhance T3JAM's activity within its specific signaling pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, reducing PI3K/AKT pathway activity. By inhibiting this pathway, T3JAM activity can be enhanced due to reduced competition from AKT-mediated phosphorylation events. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can phosphorylate and thus potentially enhance T3JAM's activity as part of the cellular adhesion signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a potent activator of the JNK/SAPK signaling pathway. This activation can lead to the phosphorylation of proteins involved in cellular adhesion, potentially enhancing T3JAM's role in these processes. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate engages sphingosine-1-phosphate receptors that can lead to the activation of signaling cascades, which may include enhancement of T3JAM activity through cross-talk with adhesion pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate T3JAM, enhancing its function in cell-cell adhesion. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor that, in a context-dependent manner, could selectively enhance T3JAM activity by inhibiting kinases that normally phosphorylate and negatively regulate T3JAM. | ||||||