T2R6 Activators
T2R6 Activators are a diverse array of chemical compounds that share the common function of enhancing the activity of the T2R6 taste receptor, which is integral to the perception of bitterness. Denatonium benzoate, with its extreme bitterness, directly activates T2R6, triggering a gustatory signaling cascade involving G protein-coupled receptors and intracellular calcium release, thereby heightening the receptor's function in taste perception.
Chloroquine and quinine hydrochloride similarly engage T2R6, with their bitter taste profiles, leading to the enhancement of the receptor's signaling pathway, and caffeine's interaction with T2R6 promotes a comparable upsurge in receptor activity, highlighting the receptor's central role in the gustatory system's response to bitter compounds. Moreover, compounds such as PROP and nicotine, by virtue of their bitter taste, directly activate T2R6, resulting in the amplification of downstream signaling events that are essential for the transduction of bitter taste signals. Magnesium sulfate and copper(II) sulfate also promote T2R6 activity through bitter taste perception pathways, ensuring the receptor's function is potentiated.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium benzoate is known for its extreme bitterness and activates taste receptor cells by binding directly to T2R6, leading to the enhancement of its functional activity by initiating the gustatory signaling cascade. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a bitter compound that can target T2R6, promoting G protein-coupled receptor signaling, leading to the release of intracellular calcium and enhancement of T2R6's role in taste perception. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine hydrochloride, another bitter compound, binds to T2R6, and through a G protein-coupled mechanism, enhances the receptor's activity, leading to increased taste signal transduction. | ||||||
Sucralose | 56038-13-2 | sc-222332 sc-222332A | 100 mg 1 g | $133.00 $463.00 | ||
Sucralose is a sweetener that can indirectly enhance T2R6 activity by modulating the sweet-bitter balance in taste signaling pathways, potentially altering T2R6's response to bitter compounds. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
Saccharin is an artificial sweetener that can activate T2R6 indirectly by competitive inhibition of sweet receptors, thereby enhancing the relative activity of bitter receptors including T2R6 in taste signal processing. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizin, a sweet-tasting compound from licorice root, may indirectly activate T2R6 by modulating the sweet-bitter taste receptor dynamics, which could lead to the upregulation of T2R6 activity in taste perception. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
PROP is known for its ability to activate bitter taste receptors, including T2R6, resulting in the activation of downstream signaling events such as phospholipase C activation and calcium signaling enhancement. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a well-known bitter compound, can activate T2R6, enhancing its signaling through the gustatory pathway, which includes G protein activation and subsequent intracellular signaling events leading to taste perception. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium sulfate has a bitter taste and can activate T2R6, leading to the enhancement of downstream signaling pathways involved in bitter taste perception, such as the release of calcium from intracellular stores. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper(II) sulfate can induce a bitter taste perception by activating T2R6, which in turn enhances gustatory signaling through mechanisms involving G protein-coupled receptor pathways and subsequent cellular responses in taste buds. | ||||||