T2R41 Inhibitors
T2R41 inhibitors pertain to a specialized group of chemical agents that target a specific subset of the taste receptor family, particularly the T2R41 receptor. The T2R41 receptor is one of the numerous bitter taste receptors identified in human physiology. These receptors are part of a larger family known as Type 2 taste receptors (T2Rs), which are G protein-coupled receptors (GPCRs) responsible for the detection of bitter compounds. T2R41 inhibitors are designed to selectively interact with the T2R41 receptor, altering its ability to bind with its natural ligands, which are typically bitter compounds. By inhibiting the normal function of the T2R41 receptor, these chemicals can modulate the perception of bitterness.
he interaction between these inhibitors and the T2R41 receptor involves complex dynamics, as the binding affinity and the resultant conformational changes in the receptor structure dictate the degree of inhibition. Researchers delve into the molecular architecture of the T2R41 receptor to ascertain the binding sites and the structural motifs that are pivotal for the receptor's activation or inhibition. The chemical structure of T2R41 inhibitors is usually characterized by the presence of functional groups that exhibit high affinity toward the receptor's active sites. Furthermore, the specificity of these inhibitors is of paramount importance to ensure that they do not cross-react with other types of T2Rs or unrelated GPCRs, maintaining a high degree of selectivity in their action. The exploration of these inhibitors encompasses a blend of chemistry, bioinformatics, and structural biology, aiming to elucidate the mechanistic pathways through which these molecules exert their effect on the T2R41 receptor.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium Benzoate is known as the most bitter compound and it is a known inhibitor of bitter taste receptors, including T2R41. By binding to the receptor's ligand-binding site, it prevents the activation of the downstream G-protein signaling cascade initiated by T2R41. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid has been shown to inhibit certain bitter taste receptors. It binds to T2R41, leading to an inhibition of its usual signaling function. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
Phenylthiourea is a compound known to specifically inhibit certain bitter taste receptors, including T2R41. It binds directly to the receptor, preventing its normal activation and subsequent bitter taste signaling. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper Sulfate is known to interact with and inhibit the function of taste receptors. It can bind to T2R41, inhibiting its signaling pathway by preventing the receptor's activation. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
Methylene Blue has been reported to inhibit certain sensory receptors. It can interact with T2R41 and prevent its usual signaling cascade. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known for its bitter taste and has been reported to inhibit bitter taste receptors. It binds to the receptor T2R41, inhibiting its activation and subsequent bitter taste signaling pathway. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
Naringin is a flavonoid that imparts a bitter taste and is known to inhibit bitter taste receptor function, including T2R41. It competes with other agonists for binding to the receptor, inhibiting its function. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a bitter compound that can inhibit the signaling of bitter taste receptors such as T2R41. It competes with other ligands for the active site of the receptor, thus inhibiting its activation. | ||||||
Sucralose | 56038-13-2 | sc-222332 sc-222332A | 100 mg 1 g | $133.00 $463.00 | ||
Sucralose, a sweetener, has been found to interact with and inhibit bitter taste receptors. By binding to T2R41, it potentially alters the receptor's conformation and inhibits its signaling activity. | ||||||