T2R41 Activators
T2R41 Activators encompass a suite of chemical compounds that directly interact with the T2R41 receptor, initiating a signaling cascade that ultimately enhances the receptor's functional activity. The activation of T2R41 by compounds such as Denatonium Benzoate, Saccharin, Quinine Hydrochloride, Chloroquine, Phenylthiocarbamide (PTC), and Caffeine occurs through direct binding to the receptor, which leads to a G-protein-coupled response and the increase of intracellular calcium levels, a definitive indicator of T2R41 activation. Other activators, such as Colchicine and Erythromycin, while having primary functions unrelated to taste, also serve as T2R41 agonists by similar mechanisms, proving the diverse ligand specificity of the receptor. Acesulfame Potassium and Propylthiouracil (PTU) further contribute to this diversity, both engaging T2R41 directly and precipitating the associated intracellular signaling events that amplify the receptor's bitter taste signaling capacity.
Additionally, natural compounds like Naringin and Magnolol are part of the T2R41 activator profile, extending the receptor's reach into phytochemical interactions. Naringin, by virtue of its presence ingrapefruits, binds to T2R41 and stimulates the same G-protein pathway as synthetic activators, underscoring the receptor's role in detecting a wide array of bitter compounds. Similarly, Magnolol interacts with T2R41, enhancing the receptor's function through its own signaling mechanism. The effect of these activators is not limited to the perception of bitterness but is integral to the modulation of various physiological processes that are mediated by T2R41. Collectively, these activators demonstrate the intricate network of chemical interactions that lead to the upregulation of T2R41's signaling pathways, thereby augmenting its sensory and potentially non-sensory roles without altering its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Denatonium benzoate | 3734-33-6 | sc-234525 sc-234525A sc-234525B sc-234525C sc-234525D | 1 g 5 g 25 g 100 g 250 g | $32.00 $47.00 $141.00 $473.00 $921.00 | ||
Denatonium Benzoate is known as one of the most bitter compounds and it activates bitter taste receptor T2R41 by directly binding to it, leading to an increase in intracellular calcium levels, which is a hallmark of T2R41 activation. | ||||||
Saccharin | 81-07-2 | sc-212902 sc-212902A sc-212902B | 100 mg 1 g 10 g | $173.00 $235.00 $286.00 | ||
Saccharin is an artificial sweetener that also has the ability to activate T2R41. Upon binding, it triggers the G-protein-coupled signaling cascade that directly enhances the activity of T2R41, resulting in the release of intracellular calcium stores. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is able to activate T2R41 by binding to the receptor, which then induces a cascade of events leading to the activation of downstream signaling pathways and an increase in intracellular calcium levels. | ||||||
N-Phenylthiourea | 103-85-5 | sc-236086 | 100 g | $319.00 | ||
PTC is a well-known bitter compound that can activate T2R41. By binding to the receptor, PTC causes a conformational change that triggers the associated G-protein signaling and the subsequent increase in intracellular calcium. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine is a bitter compound that activates T2R41 by directly interacting with the receptor, which in turn stimulates the release of calcium from intracellular stores through the G-protein signaling pathway. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine, while primarily recognized for its effects on microtubules, can also activate T2R41 by direct receptor interaction, promoting calcium signaling and enhancing the receptor's activity. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin, a macrolide antibiotic, has the capacity to activate T2R41 through direct binding to the receptor, leading to the activation of the downstream G-protein signaling cascade and calcium release. | ||||||
Acesulfame Potassium | 55589-62-3 | sc-210736 | 25 g | $245.00 | ||
Acesulfame Potassium is an artificial sweetener known to activate T2R41 by binding to the receptor, which triggers the G-protein-coupled signaling mechanism, enhancing the receptor's activity. | ||||||
6-Propyl-2-thiouracil | 51-52-5 | sc-214383 sc-214383A sc-214383B sc-214383C | 10 g 25 g 100 g 1 kg | $37.00 $56.00 $224.00 $1997.00 | ||
PTU is known to activate T2R41 by directly binding to the receptor, which initiates the downstream signaling process and increases intracellular calcium levels, thus activating the receptor. | ||||||
Naringin | 10236-47-2 | sc-203443 sc-203443A | 25 g 50 g | $45.00 $101.00 | 7 | |
Naringin, a flavonoid found in grapefruits, activates T2R41 by binding to the receptor and triggering the G-protein-coupled signaling pathway, leading to an enhancement of the receptor's function. | ||||||