Swiprosin-1 Activators
Swiprosin-1 activators represent a distinctive class of compounds known for their ability to modulate the activity of Swiprosin-1, a protein associated with various cellular functions. Swiprosin-1, also recognized as EF-hand domain-containing protein D2 (EFHD2), is predominantly expressed in immune cells and is implicated in the regulation of immune responses and cell motility. The activators targeting Swiprosin-1 operate through intricate mechanisms that involve binding to specific regions of the protein, inducing conformational changes, and consequently influencing its biological functions.
The molecular structure of Swiprosin-1 activators often exhibits a high degree of specificity, enabling selective interaction with the target protein. These compounds may possess distinct chemical moieties and functional groups that facilitate their affinity for Swiprosin-1, thereby triggering or enhancing its cellular activities. The modulation of Swiprosin-1 function by these activators has garnered attention in research exploring cellular signaling pathways, as the protein is recognized for its involvement in immune cell activation and migration. The elucidation of the molecular interactions between Swiprosin-1 and its activators provides valuable insights into the intricate regulatory networks within cells, shedding light on potential avenues for further exploration in the realm of cellular biology and signal transduction.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Swiprosin-1 has been found to be phosphorylated by PKC, leading to its enhanced function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which increases intracellular cAMP levels. Higher cAMP levels can activate PKA, which can phosphorylate and enhance the activity of Swiprosin-1. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Calcium ions can activate several signaling pathways that may enhance Swiprosin-1 activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a potent inhibitor of protein tyrosine phosphatases. Inhibition of these phosphatases might prevent Swiprosin-1 dephosphorylation, therefore maintaining its activation state. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $300.00 | ||
Calmodulin is a calcium-binding protein that can activate numerous signaling cascades after calcium influx. Calmodulin-mediated signaling pathways might enhance the activity of Swiprosin-1. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to and activates adrenergic receptors, leading to increased cAMP levels and PKA activation. PKA can phosphorylate and enhance the activity of Swiprosin-1. | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin is a phospholipase C (PLC) inhibitor. Inhibition of PLC decreases IP3 and DAG levels, which can alter calcium and PKC signaling, potentially enhancing Swiprosin-1 activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is an inhibitor of protein phosphatases 1 and 2A. Its inhibitory action can prevent Swiprosin-1 dephosphorylation, thus maintaining its activation state. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a potent activator of PKA. PKA can phosphorylate and enhance the activity of Swiprosin-1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, including PKC. However, it might indirectly enhance Swiprosin-1 function through the inhibition of other kinases. | ||||||