SV2A Activators
SV2A Activators encompass compounds that indirectly modulate the function of SV2A. These activators primarily act by influencing synaptic transmission and neuronal activity, which are integral to SV2A's role in neurotransmitter release. Compounds like Kainic Acid, AMPA, and NMDA are agonists for glutamate receptors. Their activation can enhance synaptic transmission, leading to an upregulation of SV2A activity in response to increased synaptic demand. Other molecules such as Nicotine, Varenicline, and Caffeine increase neuronal activity and neurotransmitter release. Their effects on cholinergic and other neurotransmitter systems could indirectly stimulate SV2A function.
Additionally, agents like Picrotoxin, Modafinil, Theophylline, and Baclofen modulate neuronal excitability and synaptic transmission through various mechanisms. These alterations can influence SV2A's role in synaptic vesicle cycling and neurotransmitter release. Anticonvulsants like Carbamazepine and Gabapentin, which stabilize neuronal membranes and influence GABAergic transmission, could also indirectly affect SV2A activity due to their effects on neuronal activity and synaptic dynamics. In summary, these SV2A activators represent a diverse range of compounds that potentially modulate SV2A function through indirect effects on synaptic transmission, neuronal excitability, and neurotransmitter release mechanisms. Their actions demonstrate the complex interplay between synaptic proteins and neuronal activity, highlighting the importance of modulating specific synaptic components to influence neural activity and synaptic function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Kainic acid | 487-79-6 | sc-200454 sc-200454A sc-200454B sc-200454C sc-200454D | 5 mg 25 mg 100 mg 1 g 5 g | $87.00 $370.00 $1377.00 $7803.00 $24970.00 | 12 | |
An agonist of the kainate class of glutamate receptors, potentially increasing synaptic activity and indirectly influencing SV2A-mediated neurotransmitter release. | ||||||
N-Methyl-D-Aspartic acid (NMDA) | 6384-92-5 | sc-200458 sc-200458A | 50 mg 250 mg | $109.00 $369.00 | 2 | |
A specific agonist for NMDA receptors, which could indirectly stimulate SV2A function due to heightened synaptic activity. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
A stimulant that increases neuronal activity, potentially indirectly enhancing SV2A function due to increased neurotransmitter release. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
A GABA_A receptor antagonist that can enhance neuronal excitability, potentially affecting SV2A activity by increasing synaptic demand. | ||||||
Modafinil | 68693-11-8 | sc-507327 | 10 mg | $99.00 | ||
A wakefulness-promoting agent that increases synaptic neurotransmitter release, possibly influencing SV2A function. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
A phosphodiesterase inhibitor, which can increase cAMP levels and potentially enhance SV2A activity in response to increased neuronal activity. | ||||||
(±)-Baclofen | 1134-47-0 | sc-200464 sc-200464A | 1 g 5 g | $56.00 $258.00 | ||
A GABA_B receptor agonist, which may indirectly affect SV2A activity in GABAergic neurons by modulating synaptic transmission. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
An anticonvulsant that stabilizes neuronal membranes, potentially influencing SV2A function indirectly through effects on synaptic activity. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $53.00 $94.00 $135.00 | 7 | |
A GABA analogue that can influence neuronal excitability, potentially affecting SV2A activity in response to changes in synaptic transmission. | ||||||