Molecular structure of Kainic acid, CAS Number: 487-79-6
Kainic acid (CAS 487-79-6)
See product citations (12)
Alternate Names:
2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine; Digenic acid
Application:
Kainic acid is an excitatory and excitotoxic glutamate-mimic kainate receptor agonist
CAS Number:
487-79-6
Purity:
≥98%
Molecular Weight:
213.23
Molecular Formula:
C10H15NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kainic acid is a marine natural product bearing structural analogy to the neurotransmitter glutamate that produces neuroexcitatory agonist effects at the kainate ionotropic receptors. The kainate receptors are non-NMDA glutamate-recognizing ionotropic receptors, and agonism by kainic acid or glutamate produces excitation and contribution to excitatory postsynaptic currents. Agonism of the kainate receptors by sufficient concentrations of kainic acid produces excitotoxicity, and kainic acid is widely employed as a tool for inducing excitotoxic seizures in neurotransmission studies. Kainic acid is employed alongside the agonists NMDA (sc-200458) and AMPA (sc-200437) to identify the specific subtype of glutamate-recognizing receptors of interest. A caged version of this compound is available (MNI caged kainic acid, sc-359014).
Kainic acid (CAS 487-79-6) References
- Kainic acid-induced seizures in aged rats: neurochemical correlates. | Dawson, R. and Wallace, DR. 1992. Brain Res Bull. 29: 459-68. PMID: 1393617
- Kainate receptors and synaptic transmission. | Huettner, JE. 2003. Prog Neurobiol. 70: 387-407. PMID: 14511698
- CB1 cannabinoid receptors and on-demand defense against excitotoxicity. | Marsicano, G., et al. 2003. Science. 302: 84-8. PMID: 14526074
- Intrahippocampal kainic acid reduces glutamine synthetase. | Waniewski, RA. and McFarland, D. 1990. Neuroscience. 34: 305-10. PMID: 1970631
- Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze. | Frye, CA. and Walf, A. 2011. Dev Neurobiol. 71: 142-52. PMID: 20715152
- Houttuyniae Herba Attenuates Kainic Acid-Induced Neurotoxicity via Calcium Response Modulation in the Mouse Hippocampus. | Kim, HG., et al. 2015. Planta Med. 81: 1697-704. PMID: 26366753
- Kainic acid differentially affects the synaptosomal release of endogenous and exogenous amino acidic neurotransmitters. | Poli, A., et al. 1985. J Neurochem. 45: 1677-86. PMID: 2865332
- Effects of kainic acid on seizure susceptibility in the developing brain. | Holmes, GL. and Thompson, JL. 1988. Brain Res. 467: 51-9. PMID: 3359330
- Kainic acid: a powerful neurotoxic analogue of glutamate. | Olney, JW., et al. 1974. Brain Res. 77: 507-12. PMID: 4152936
- Excitatory amino acid transmitters. | Watkins, JC. and Evans, RH. 1981. Annu Rev Pharmacol Toxicol. 21: 165-204. PMID: 6112965
- Kainic acid stimulates excitatory amino acid neurotransmitter release at presynaptic receptors. | Ferkany, JW., et al. 1982. Nature. 298: 757-9. PMID: 6287270
- Kainic acid derivatives with anticonvulsant activity. | Collins, JF., et al. 1984. Neurosci Lett. 51: 371-6. PMID: 6521964
- Kainic acid and 1'-hydroxykainic acid from Palmariales. | Ramsey, UP., et al. 1994. Nat Toxins. 2: 286-92. PMID: 7866664
- Kainic acid induces apoptosis in neurons. | Simonian, NA., et al. 1996. Neuroscience. 75: 1047-55. PMID: 8938740
Inhibitor of:
dendrin, and SYNDIG1.Activator of:
advillin, CGRP1, CNIH3, Complexin-2, EAAT3, EF-CBP1, EG632778, Egr-2, FAM194B, GABAB R1β, GKAP, gliacolin, GluR-δ2, GluR-5, GPR85, Grid2, HMX2, HuB, KCTD3, LRFN4, MAP-2B, NCDN, NETO1, Neurexophilin-2, Neuroglycan C, neuroligin X, Neuromedin N, NP2, NPAS1, PCDHBPcdhb22, PNMAL1, Relaxin 3, SAPAP3, SRPX2, SV2A, Tachykinin 4, TULP3, V1RH6, V1RH8, V1RI1, V1RI2, V1RI4, V1RI6, V1RI7, VILIP-3, Vmn1r104, Vmn2r107, Vmn2r109, Vmn2r111, Vmn2r113, Vmn2r115, Vmn2r13, Vmn2r16, Vmn2r62, Vmn2r65, Vmn2r67, Vmn2r69, Vmn2r70, Vmn2r72, Vmn2r74, Vmn2r76, Vmn2r78, Vmn2r80, Vmn2r82, Vmn2r84, Vmn2r91, Vmn2r93, Vmn2r95, Vmn2r97, and Vmn2r99.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kainic acid, 5 mg | sc-200454 | 5 mg | $85.00 | |||
Kainic acid, 25 mg | sc-200454A | 25 mg | $370.00 | |||
Kainic acid, 100 mg | sc-200454B | 100 mg | $1350.00 | |||
Kainic acid, 1 g | sc-200454C | 1 g | $7650.00 | |||
Kainic acid, 5 g | sc-200454D | 5 g | $24480.00 |