SUV420H1 Activators
The chemical class known as SUV420H1 Activators comprises a set of compounds that can modulate the activity of the histone methyltransferase enzyme SUV420H1. These compounds play a pivotal role in epigenetic regulation by influencing histone methylation patterns, thereby affecting chromatin structure and gene expression. SUV420H1 is primarily responsible for catalyzing the di-methylation of histone H4 lysine 20 (H4K20me2), which is a crucial mark associated with heterochromatin formation and genomic stability.
SUV420H1 activators exert their effects through two main mechanisms: direct activation and indirect modulation. Direct activators are chemical compounds like A-196 that specifically interact with SUV420H1, enhancing its enzymatic activity. This direct interaction can lead to increased levels of H4K20me2, promoting the formation of heterochromatin and influencing gene expression profiles. On the other hand, indirect activators, including compounds like DZNep or GSK-J4, impact SUV420H1 activity by targeting other epigenetic regulators. For instance, DZNep inhibits EZH2, an enzyme involved in histone methylation, and its inhibition can indirectly influence SUV420H1-mediated histone methylation patterns. Likewise, GSK-J4 inhibits KDM6B (JMJD3), a histone demethylase, indirectly affecting SUV420H1-mediated epigenetic modifications.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA demethylating agent that indirectly influences SUV420H1 by altering DNA methylation patterns, which can impact chromatin structure and gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that indirectly activates SUV420H1 by increasing histone acetylation levels, potentially leading to changes in chromatin structure. | ||||||
UNC0638 | 1255580-76-7 | sc-397012 | 10 mg | $315.00 | ||
UNC0638 is a selective inhibitor of the histone methyltransferase G9a/GLP. By inhibiting G9a, UNC0638 can indirectly impact SUV420H1-mediated histone methylation. | ||||||
JIB 04 | 199596-05-9 | sc-397040 | 20 mg | $177.00 | ||
JIB-04 is a histone demethylase inhibitor that indirectly influences SUV420H1 by modulating histone methylation patterns, which can affect chromatin structure. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4 is a specific inhibitor of the histone demethylase KDM6B (JMJD3). Inhibition of KDM6B by GSK-J4 can indirectly impact SUV420H1-mediated histone methylation. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is a selective inhibitor of the histone methyltransferase G9a/GLP. By inhibiting G9a, BIX-01294 indirectly influences SUV420H1-mediated histone methylation. | ||||||
Difluoromethylornithine | 70052-12-9 | sc-204723 sc-204723A sc-204723B sc-204723C sc-204723D sc-204723E | 10 mg 25 mg 100 mg 250 mg 1 g 5 g | $59.00 $133.00 $161.00 $317.00 $983.00 $4821.00 | 2 | |
DFMO is an inhibitor of ornithine decarboxylase (ODC), which indirectly influences SUV420H1 by impacting polyamine metabolism and potentially chromatin structure. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A is an antibiotic that indirectly affects SUV420H1 by binding to GC-rich DNA regions, potentially influencing chromatin structure. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is a natural compound that indirectly influences SUV420H1 by modulating NF-κB signaling, which can impact gene expression and chromatin structure. | ||||||
A-196 | 1982372-88-2 | sc-507414 | 1 mg | $72.00 | ||
A-196 is a potent and selective inhibitor of the histone methyltransferase SUV420H1. By directly targeting SUV420H1, A-196 can promote its activity and influence histone methylation. | ||||||