SUR-1 Inhibitors
SUR-1 inhibitors, short for Sulfonylurea receptor 1 inhibitors, belong to a specific chemical class of compounds that play a crucial role in regulating insulin secretion within pancreatic beta cells. These inhibitors target a specific protein known as the sulfonylurea receptor 1 (SUR-1), which is an integral part of the ATP-sensitive potassium (KATP) channels found in these cells. The primary function of KATP channels is to modulate the flow of potassium ions across the cell membrane, which in turn influences the electrical activity of the beta cells and insulin release. SUR-1 inhibitors exert their effects by binding to the SUR-1 subunit, thereby altering the activity of KATP channels and indirectly regulating insulin secretion.
The mechanism of action of SUR-1 inhibitors is intricately linked to their ability to block KATP channels, resulting in membrane depolarization and subsequent opening of voltage-gated calcium channels. This leads to an influx of calcium ions into the beta cells, triggering the release of insulin-containing vesicles into the bloodstream. By modulating the activity of SUR-1, these inhibitors essentially fine-tune the delicate balance between insulin production and secretion, making them valuable tools for understanding the physiological processes that underlie glucose homeostasis. Researchers and scientists have been keenly interested in studying SUR-1 inhibitors to gain insights into the intricacies of insulin regulation and its relevance in various physiological and pathological conditions, paving the way for applications in the field of diabetes research and beyond.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
Diazoxide opens the ATP-sensitive potassium channels by binding to the SUR-1 subunit, resulting in reduced insulin secretion from pancreatic beta cells. This action indirectly decreases SUR-1 expression by reducing cellular demand for this protein. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine indirectly inhibits SUR-1 expression by blocking the ATP-sensitive potassium channels. This alteration in channel activity can lead to decreased stability and expression of SUR-1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
As a calcium channel blocker, nifedipine indirectly affects SUR-1 expression by altering intracellular calcium levels, influencing the activity and stability of the ATP-sensitive potassium channels and subsequently the SUR-1 subunit. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $46.00 $61.00 $117.00 $173.00 $530.00 | 36 | |
Glyburide, a sulfonylurea, binds to SUR-1, closing the ATP-sensitive potassium channels and promoting insulin secretion. Chronic exposure to glyburide may lead to a compensatory downregulation of SUR-1 expression. | ||||||
Tolbutamide | 64-77-7 | sc-203298 | 5 g | $44.00 | 2 | |
Tolbutamide, a sulfonylurea, interacts with SUR-1 to close ATP-sensitive potassium channels. Similar to glyburide, long-term exposure to tolbutamide may result in decreased SUR-1 expression. | ||||||
Chlorpropamide | 94-20-2 | sc-234350 | 25 g | $73.00 | 7 | |
Chlorpropamide, a first-generation sulfonylurea, interacts with SUR-1 to close ATP-sensitive potassium channels. Long-term use of chlorpropamide may lead to decreased expression of SUR-1. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone, a thiazolidinedione, improves insulin sensitivity. While its primary action is on peroxisome proliferator-activated receptor gamma, it may indirectly influence SUR-1 expression through its effects on insulin signaling pathways. | ||||||
Pioglitazone hydrochloride | 112529-15-4 | sc-204848 sc-204848A | 100 mg 500 mg | $63.00 $213.00 | 19 | |
Pioglitazone hydrochloride, another thiazolidinedione, works similarly to rosiglitazone and may have indirect effects on SUR-1 expression through its influence on insulin sensitivity and signaling pathways. | ||||||