ss DNA marker Inhibitors
ss DNA marker inhibitors are compounds that play crucial roles in modulating the replication of single-stranded DNA (ss DNA). One significant category within this class includes agents such as Cisplatin. Cisplatin directly influences ss DNA markers by forming intrastrand crosslinks within the DNA structure. These crosslinks interfere with the normal separation of DNA strands during replication, acting as potent inhibitors of ss DNA synthesis. Nucleoside analogs like Gemcitabine represent another subgroup of ss DNA marker inhibitors. Gemcitabine incorporates into growing DNA chains, leading to chain termination and disrupting DNA synthesis. This incorporation interferes with the elongation process during DNA replication, indirectly inhibiting the progression of ss DNA regions. Similarly, 5-Fluorouracil disrupts DNA synthesis by inhibiting thymidylate synthase, affecting the de novo synthesis of thymidine and impeding ss DNA replication processes.
Agents like Aphidicolin and Camptothecin directly interfere with DNA polymerases and topoisomerases, respectively. Aphidicolin inhibits DNA polymerases α, δ, and ε, crucial for both leading and lagging strand synthesis. Its interference disrupts the progression of DNA replication, affecting ss DNA regions. Camptothecin, on the other hand, inhibits DNA topoisomerase I, generating DNA strand breaks during replication and directly impacting ss DNA synthesis. Inhibitors such as ATR Inhibitor (VE-821) and DNA-PK Inhibitor (NU7441) act indirectly by targeting key players in the DNA damage response. VE-821 suppresses the ATR kinase, critical for replication fork stability, indirectly influencing ss DNA markers by compromising the response to replication stress. NU7441 inhibits DNA-dependent protein kinase (DNA-PK), impacting the repair of replication-associated lesions and indirectly modulating ss DNA regions. In summary, the ss DNA marker inhibitors class encompasses a diverse range of chemicals that exert their effects through various mechanisms, directly or indirectly interfering with key processes involved in ss DNA replication.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A platinum-based chemotherapeutic agent that forms DNA adducts, inducing DNA damage and inhibiting DNA replication. Cisplatin directly modulates ss DNA markers by forming intrastrand crosslinks, impeding DNA strand separation and inhibiting the progression of DNA replication. | ||||||
2′-Deoxy-2′,2′-difluorocytidine | 95058-81-4 | sc-275523 sc-275523A | 1 g 5 g | $56.00 $128.00 | ||
A nucleoside analog that incorporates into DNA strands, leading to chain termination. Gemcitabine indirectly inhibits ss DNA markers by disrupting DNA synthesis. Its incorporation into growing DNA chains interferes with the elongation process, ultimately hindering the replication of single-stranded DNA regions. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
A pyrimidine analog that inhibits thymidylate synthase, disrupting DNA synthesis. 5-Fluorouracil indirectly modulates ss DNA markers by interfering with the de novo synthesis of thymidine, a critical component for DNA replication. This disruption leads to an overall inhibition of single-stranded DNA replication processes. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
An inhibitor of ribonucleotide reductase, reducing the pool of deoxyribonucleotides. Hydroxyurea indirectly influences ss DNA markers by limiting the availability of precursors necessary for DNA synthesis. The decreased supply of deoxyribonucleotides hampers the progression of DNA replication, affecting single-stranded DNA regions. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
A reversible inhibitor of DNA polymerase α, δ, and ε. Aphidicolin directly modulates ss DNA markers by inhibiting DNA polymerases involved in the synthesis of both leading and lagging strands. Its interference with polymerase activity disrupts the normal progression of DNA replication, impacting the synthesis of single-stranded DNA regions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
An inhibitor of DNA topoisomerase I, inducing DNA strand breaks. Camptothecin directly influences ss DNA markers by generating DNA breaks during replication. The formation of covalent topoisomerase-DNA complexes interferes with normal DNA unwinding and synthesis, leading to disruptions in the replication of single-stranded DNA regions. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
A DNA crosslinking agent forming interstrand crosslinks. Mitomycin C directly modulates ss DNA markers by inducing crosslinks, impeding the separation of DNA strands during replication. The crosslinked DNA structure hinders the progression of DNA replication, particularly affecting the synthesis of single-stranded DNA regions. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
An inhibitor of the ATR kinase involved in DNA damage response. VE-821 indirectly influences ss DNA markers by suppressing the ATR pathway, which is crucial for maintaining replication fork stability. Inhibition of ATR compromises the ability to cope with replication stress, impacting the progression of DNA replication, including that of single-stranded DNA regions. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
An inhibitor of DNA-dependent protein kinase (DNA-PK), involved in DNA repair. NU7441 indirectly modulates ss DNA markers by impeding the DNA-PK-dependent repair pathways. Inhibition of DNA-PK disrupts the normal response to DNA damage, affecting the processing of replication-associated lesions and influencing the replication of single-stranded DNA regions. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
A glycopeptide antibiotic causing DNA strand breaks. Bleomycin directly influences ss DNA markers by inducing oxidative DNA damage and generating single- and double-strand breaks. Its mechanism of action disrupts the normal progression of DNA replication, particularly impacting the synthesis of single-stranded DNA regions. | ||||||