SREBP-2 Activators
Common SREBP-2 Activators include, but are not limited to Atorvastatin CAS 134523-00-5, 25-Hydroxycholesterol CAS 2140-46-7, Amlodipine besylate CAS 111470-99-6, Geldanamycin CAS 30562-34-6 and Insulin CAS 11061-68-0.
Sterol Regulatory Element-Binding Proteins, or SREBPs, are a class of transcription factors that play a crucial role in regulating lipid metabolism and cholesterol homeostasis in mammals. SREBP-2 specifically focuses on the regulation of cholesterol synthesis and uptake. SREBP-2 activators are molecules or compounds that influence the activity of SREBP-2, leading to the modulation of cholesterol metabolism within cells.
SREBP-2 primarily functions as a transcription factor that controls the expression of genes involved in cholesterol biosynthesis and uptake. When cellular cholesterol levels are low, SREBP-2 is proteolytically cleaved, allowing its active fragment to enter the nucleus and bind to specific DNA sequences called sterol regulatory elements (SREs). This binding, in turn, leads to the upregulation of genes encoding enzymes and proteins involved in cholesterol synthesis and the LDL receptor, which is responsible for cholesterol uptake from the bloodstream. By activating SREBP-2, cells can increase their capacity to synthesize and acquire cholesterol, maintaining cholesterol homeostasis. Consequently, SREBP-2 activators may serve as research tools to study lipid metabolism and its impact on conditions like hypercholesterolemia, atherosclerosis, and other lipid-related disorders.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
These cholesterol-lowering suggested compounds inhibit HMG-CoA reductase, leading to a decrease in cellular cholesterol and a compensatory increase in SREBP-2 to boost cholesterol synthesis. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
A calcium channel blocker that, in some studies, has been shown to upregulate SREBP-2 expression. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
An Hsp90 inhibitor that can enhance SREBP-2 activation and increase target gene expression. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Can enhance SREBP-2 processing and increase its target genes, promoting cholesterol synthesis. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Induces endoplasmic reticulum (ER) stress and can influence SREBP-2 processing and expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Another inducer of ER stress, which might modulate SREBP-2 expression. | ||||||
Betulin | 473-98-3 | sc-234016 | 1 g | $102.00 | 5 | |
A pentacyclic triterpenoid that inhibits SREBP activation and may influence SREBP-2. | ||||||
S-Nitrosoglutathione (GSNO) | 57564-91-7 | sc-200349 sc-200349B sc-200349A sc-200349C | 10 mg 25 mg 50 mg 100 mg | $87.00 $210.00 $346.00 $449.00 | 15 | |
Nitric oxide can modulate SREBP-2 processing and activation under certain conditions. | ||||||
Docosa-4Z,7Z,10Z,13Z,16Z,19Z-hexaenoic Acid (22:6, n-3) | 6217-54-5 | sc-200768 sc-200768A sc-200768B sc-200768C sc-200768D | 100 mg 1 g 10 g 50 g 100 g | $94.00 $210.00 $1779.00 $8021.00 $16657.00 | 11 | |
Fatty acids can modulate SREBP-2 activation and expression, generally inhibiting its activity. | ||||||