Srb4 Activators
Srb4, standing for Suppressor of RNA polymerase B 4, is a component of the mediator complex in the yeast Saccharomyces cerevisiae. The mediator complex is a critical multi-protein assembly that plays a pivotal role in the regulation of gene transcription. It acts as a bridge, connecting transcription factors to RNA polymerase II, thus facilitating the transcription of genes into messenger RNA.
Srb4 is particularly significant as it is part of the core module of the mediator complex. This core module is essential for the mediator's interaction with RNA polymerase II and for the integrity of the entire mediator complex. The role of Srb4 and the mediator complex extends beyond mere transcription initiation; it is involved in various stages of the transcription cycle, including pause release and elongation.The mediator complex, inclusive of Srb4, is also crucial in conveying regulatory signals to RNA polymerase II. This includes responses to environmental cues, thus allowing the cell to adapt its gene expression profile in response to changes in its environment. The mediator complex thereby acts as an integrator of multiple signaling pathways that regulate gene expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA, a histone deacetylase inhibitor, might upregulate Srb4 expression by altering chromatin structure and enhancing transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, could influence Srb4 expression by changing DNA methylation patterns. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin might affect Srb4 expression through its role in the mTOR signaling pathway, which is involved in cell growth and metabolism. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine, a cyclin-dependent kinase inhibitor, could potentially modulate Srb4 expression by influencing cell cycle-related transcription. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride may influence Srb4 expression through pathways related to mood regulation and cellular stress response. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, could upregulate Srb4 expression by affecting chromatin accessibility and gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid might modulate Srb4 expression as part of its role in cellular differentiation and gene regulation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea, inducing DNA damage response, may affect Srb4 expression as part of the cellular stress response mechanism. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 could influence Srb4 expression through its role in gene regulation and cellular metabolism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may modulate Srb4 expression through its anti-inflammatory properties and effects on transcriptional regulation. | ||||||