Date published: 2025-9-17

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SR-3A Activators

The SR-3A Activators chemical class encompasses a range of compounds that can modulate the activity of serotonin receptor 3A (HTR3A). These compounds primarily function by influencing serotonin signaling pathways, either by directly affecting serotonin levels or by modulating the receptor's interaction with its ligands. Key members of this class, such as Serotonin, 5-HTP, Tryptophan, and various selective serotonin reuptake inhibitors (SSRIs) like Fluoxetine, Sertraline, Citalopram, and Escitalopram, demonstrate potential in enhancing HTR3A activation. Serotonin, as the natural ligand for HTR3A, directly activates the receptor. 5-HTP and Tryptophan, as precursors to serotonin, indirectly increase serotonin levels, thereby enhancing HTR3A activation. SSRIs, by inhibiting the reuptake of serotonin, increase its availability in the synaptic cleft, which can lead to enhanced activation of HTR3A. Other notable compounds in this class, including MDMA, Psilocybin, LSD, Buspirone, and Ondansetron, offer diverse mechanisms for modulating HTR3A activity. MDMA and psychedelic compounds like Psilocybin and LSD are known to affect serotonin receptors, thereby influencing HTR3A activation. Buspirone, as a serotonin receptor agonist, directly interacts with serotonin receptors and may enhance HTR3A activation. Ondansetron, primarily an antagonist at serotonin receptors, provides insights into the receptor's modulation and potential indirect effects on HTR3A activation.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

SR 57227 hydrochloride

77145-61-0sc-204301
sc-204301A
10 mg
50 mg
$148.00
$559.00
(0)

SR 57227 hydrochloride, an SR-3A compound, exhibits intriguing electronic properties due to its unique arrangement of functional groups. The presence of halide ions enhances its reactivity, allowing for selective nucleophilic attacks. Its ability to form stable complexes with metal ions is notable, influencing coordination chemistry. Additionally, the compound's polar nature affects its solvation dynamics, leading to distinct reaction pathways and kinetics in various environments.

1-Phenylbiguanide hydrochloride

55-57-2sc-203455
100 mg
$59.00
(0)

1-Phenylbiguanide hydrochloride, classified as an SR-3A compound, showcases remarkable hydrogen bonding capabilities, which significantly influence its solubility and interaction with solvents. Its unique structural features facilitate specific intermolecular interactions, enhancing its stability in various conditions. The compound's ability to engage in tautomeric shifts can lead to diverse reaction mechanisms, while its distinct electronic configuration contributes to its reactivity in complexation reactions.

Serotonin hydrochloride

153-98-0sc-201146
sc-201146A
100 mg
1 g
$116.00
$183.00
15
(1)

The primary ligand for serotonin receptors, serotonin can activate HTR3A directly by binding to the receptor.

RS 56812 hydrochloride

143137-35-3sc-361315
sc-361315A
10 mg
50 mg
$200.00
$902.00
(0)

RS 56812 hydrochloride, an SR-3A compound, exhibits intriguing electrostatic interactions due to its polar functional groups, which enhance its affinity for various substrates. Its unique conformation allows for selective binding to target sites, influencing reaction pathways. The compound's dynamic equilibrium between different tautomeric forms can alter its reactivity, while its robust intermolecular forces contribute to its stability in diverse environments, making it a subject of interest in chemical studies.

5-Hydroxy Tryptophan

56-69-9sc-217201
5 g
$428.00
(0)

A precursor to serotonin, 5-HTP can increase serotonin levels, potentially enhancing HTR3A activation.

L-Tryptophan

73-22-3sc-280888
sc-280888A
sc-280888B
100 g
1 kg
5 kg
$126.00
$357.00
$1760.00
(0)

The amino acid precursor to serotonin, which can indirectly increase serotonin levels and influence HTR3A activity.

Fluoxetine

54910-89-3sc-279166
500 mg
$312.00
9
(1)

A selective serotonin reuptake inhibitor (SSRI), can increase serotonin availability, potentially enhancing HTR3A activation.

Sertraline hydrochloride

79559-97-0sc-201104
sc-201104A
sc-201104B
10 mg
50 mg
100 mg
$67.00
$102.00
$153.00
2
(1)

Another SSRI, increases serotonin levels in the synaptic cleft, potentially affecting HTR3A activation.

Escitalopram

128196-01-0sc-357349
sc-357349A
10 mg
50 mg
$128.00
$408.00
2
(0)

An SSRI, increases extracellular serotonin levels, potentially enhancing HTR3A activation.

Buspirone

36505-84-7sc-504347
2.5 g
$295.00
1
(0)

A serotonin receptor agonist, can potentially enhance HTR3A activation.