SR-3A Antibody (A-9): sc-390168

SR-3A Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SR-3A of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SR-3A (A-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SR-3A, also known as the 5-Hydroxytryptamine Receptor 3A, plays a crucial role as a ligand-gated ion channel that mediates the effects of serotonin, a key neurotransmitter involved in numerous physiological processes. SR-3A location in the cell membrane allows for rapid transmission of signals in response to serotonin binding, which is essential for regulating functions such as mood, anxiety, and gastrointestinal motility. Dysregulation of SR-3A can lead to various disorders, including anxiety and depression, highlighting SR-3A significance in both the central and peripheral nervous systems. Using anti-SR-3A antibody (A-9) in research can provide valuable insights into the mechanisms of serotonin signaling and its implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SR-3A Antibody (A-9) References:

1. Serotonin 2B receptor is required for heart development.  |  Nebigil, CG., et al. 2000. Proc Natl Acad Sci U S A. 97: 9508-13. PMID: 10944220
2. Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice.  |  Gingrich, JA. and Hen, R. 2001. Psychopharmacology (Berl). 155: 1-10. PMID: 11374326
3. Definition of pharmacological receptors.  |  Kenakin, TP., et al. 1992. Pharmacol Rev. 44: 351-62. PMID: 1438521
4. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.  |  Maricq, AV., et al. 1991. Science. 254: 432-7. PMID: 1718042
5. [Cortical 5-hydroxytryptamine receptor 3A (Htr3a) positive inhibitory neurons: diversity in type and function].  |  Wu, JY., et al. 2021. Sheng Li Xue Bao. 73: 295-305. PMID: 33903891
6. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome.  |  Gelernter, J., et al. 1995. Genomics. 26: 207-9. PMID: 7601444
7. Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.  |  Ruat, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 8547-51. PMID: 8397408
8. Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2.  |  Weiss, B., et al. 1995. Genomics. 29: 304-5. PMID: 8530095
9. Central 5-HT4 receptors.  |  Eglen, RM., et al. 1995. Trends Pharmacol Sci. 16: 391-8. PMID: 8578609
10. Assignment of 5-hydroxytryptamine receptor (HTR4) to human chromosome 5 bands q31-->q33 by in situ hybridization.  |  Claeysen, S., et al. 1997. Cytogenet Cell Genet. 78: 133-4. PMID: 9371406
11. Signaling pathways mediating induction of the early response genes prostaglandin G/H synthase-2 and egr-1 by serotonin via 5-HT2A receptors.  |  Goppelt-Struebe, M. and Stroebel, M. 1998. J Cell Physiol. 175: 341-7. PMID: 9572479
12. The 5-HT3B subunit is a major determinant of serotonin-receptor function.  |  Davies, PA., et al. 1999. Nature. 397: 359-63. PMID: 9950429

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SR-3A Antibody (A-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SR-3A Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SR-3A Antibody (A-9) Specifications

Alternate Product Name: HTR3A

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 341-478

Epitope Target: SR-3A

Epitope Species: human

Product Reactivity/Detection: SR-3A

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SR-3A Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin