SPTSSA Activators
SPTSSA, or Serine Palmitoyltransferase Small Subunit A, is a crucial component of the serine palmitoyltransferase (SPT) enzyme complex. This complex catalyzes the initial step in sphingolipid biosynthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine. Sphingolipids are not only structural elements of cell membranes but also play pivotal roles in signal transduction and cell recognition.
The SPTSSA subunit is essential for the stabilization and localization of the SPT complex within the cell. It is involved in the regulation of the complex's activity, influencing the rate of sphingolipid production. Proper functioning of this enzyme is critical, as imbalances in sphingolipid levels are associated with various diseases, including metabolic disorders and neurodegenerative diseases like Alzheimer's.SPTSSA itself is regulated by various mechanisms within the cell, ensuring that sphingolipid synthesis is tightly controlled. Factors that influence cellular lipid composition, energy balance, and stress responses can alter SPTSSA expression. For example, nutrient availability, metabolic demands, and exposure to toxins can modulate the activity of the SPT complex through changes in SPTSSA levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $112.00 $280.00 | 2 | |
As a substrate for SPT, excess palmitic acid might enhance SPTSSA expression to increase sphingolipid production. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
A sphingolipid that could modulate its own synthesis by regulating SPTSSA expression. | ||||||
C2 Ceramide | 3102-57-6 | sc-201375 sc-201375A | 5 mg 25 mg | $77.00 $316.00 | 12 | |
As part of the sphingolipid pathway, ceramide levels could influence SPTSSA expression through feedback mechanisms. | ||||||
Matrine | 519-02-8 | sc-205741 sc-205741A | 100 mg 500 mg | $242.00 $544.00 | ||
An alkaloid that may affect multiple signaling pathways, potentially altering SPTSSA expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
A triterpenoid that can induce stress responses, possibly impacting SPTSSA expression. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
An inhibitor of HMG-CoA reductase that may have off-target effects on other lipid-related enzymes, including SPTSSA. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Similar to lovastatin, could indirectly affect SPTSSA expression through its role in lipid metabolism. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that may alter lipid metabolism and thus SPTSSA expression. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
A PPAR-gamma agonist that regulates lipid metabolism, potentially affecting SPTSSA expression. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $32.00 $36.00 $51.00 | 1 | |
Essential for phospholipid synthesis, choline availability might influence sphingolipid synthesis and SPTSSA expression. | ||||||