SPTLC3 Inhibitors
SPTLC3 inhibitors are chemical compounds that inhibit Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3). SPTLC3 is a subunit of the serine palmitoyltransferase (SPT) enzyme complex, which plays a pivotal role in sphingolipid metabolism by catalyzing the first step in the synthesis of these important lipids. The regulation of sphingolipid synthesis is crucial as these lipids are key components of cell membranes and are involved in various cellular functions, including signal transduction and cell-cell interactions. Inhibitors of SPTLC3 specifically interact with this subunit, thereby influencing the overall activity of the SPT complex.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
A diterpene triepoxide that can inhibit global transcription, potentially affecting SPTLC3 mRNA levels. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that may alter gene expression patterns, possibly leading to decreased SPTLC3 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
An inhibitor of DNA topoisomerase I, leading to DNA damage and potential downregulation of gene expression including SPTLC3. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol that can modulate gene expression by affecting epigenetic markers, possibly impacting SPTLC3 levels. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II transcription elongation, possibly reducing SPTLC3 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA synthesis, possibly leading to decreased transcription of SPTLC3. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
A potent inhibitor of RNA polymerase II, which could suppress transcription of SPTLC3 mRNA. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Inhibit NF-kB activation which might downregulate SPTLC3 expression indirectly. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can change chromatin structure and gene expression, potentially affecting SPTLC3. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Affects gene expression and cell differentiation, which might indirectly decrease SPTLC3 expression. | ||||||