SPT16 Activators
SPT16 Activators belong to a specialized category of chemical compounds designed to modulate the activity of the SPT16 protein, also known as suppressor of Ty 16. SPT16 is a highly conserved protein that plays an essential role in chromatin remodeling and transcriptional regulation. It is a subunit of the facilitates chromatin transcription (FACT) complex, which is involved in the dynamic alteration of chromatin structure during transcription, replication, and repair of DNA. SPT16, in particular, functions as a histone chaperone, facilitating the disassembly of nucleosomes and promoting the smooth passage of RNA polymerase during transcription.
SPT16 Activators are compounds engineered to interact with SPT16 and influence its functions within the FACT complex. These activators can either enhance or inhibit SPT16's role in nucleosome disassembly and chromatin remodeling, depending on their chemical structure and mode of action. By targeting SPT16, these compounds provide researchers with a tool to investigate the dynamic processes of chromatin remodeling, transcriptional regulation, and DNA repair. The study of SPT16 Activators is crucial for advancing our understanding of the molecular mechanisms underlying gene expression and chromatin structure, as well as how perturbations in these processes can impact cellular functions and contribute to various diseases, including cancer. Researchers continue to explore the precise mechanisms of SPT16 activation and its implications in cellular physiology, offering insights into the complex interplay between chromatin dynamics and gene regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylases (HDACs), leading to a more relaxed chromatin state that may enhance the activity of the FACT complex, including SPT16. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
An HDAC inhibitor that, by altering chromatin structure, could indirectly facilitate SPT16 function in chromatin remodeling. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Another HDAC inhibitor, potentially influencing the chromatin landscape and indirectly affecting SPT16's role in transcription. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
A short-chain fatty acid that acts as an HDAC inhibitor, possibly affecting chromatin dynamics and thereby SPT16 activity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Primarily known as an anticonvulsant, it also serves as an HDAC inhibitor and could indirectly influence SPT16 activity. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Specifically targets HDACs, modifying chromatin structure and possibly impacting SPT16's function. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
An HDAC inhibitor that could modulate chromatin structure, potentially affecting the activity of SPT16 within the FACT complex. | ||||||
CI 994 | 112522-64-2 | sc-205245 sc-205245A | 10 mg 50 mg | $97.00 $525.00 | 1 | |
An HDAC inhibitor, potentially altering chromatin organization and indirectly impacting SPT16 activity. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Known to inhibit HDACs, it may influence the chromatin environment and indirectly affect SPT16's function. | ||||||
JNJ-26481585 | 875320-29-9 | sc-364515 sc-364515A | 5 mg 50 mg | $321.00 $1224.00 | ||
An HDAC inhibitor that may alter the chromatin state, potentially impacting the activity of SPT16 in transcription. | ||||||