Sphingomyelin Synthase 1 Inhibitors
Sphingomyelin Synthase 1 (SMS1) inhibitors are a class of chemical compounds that specifically target and inhibit the activity of SMS1, an enzyme responsible for the biosynthesis of sphingomyelin from ceramide and phosphatidylcholine. Sphingomyelin is a key component of cell membranes, particularly in myelin sheaths, where it contributes to membrane stability and fluidity. It also plays an essential role in cell signaling and communication. SMS1 catalyzes the transfer of a phosphocholine group to ceramide, resulting in the formation of sphingomyelin, which is crucial for maintaining lipid homeostasis within the cell. Inhibitors of SMS1 disrupt this biosynthetic pathway, potentially leading to altered sphingomyelin levels and impacting various cellular functions that depend on this important lipid.
The mechanism of action of SMS1 inhibitors typically involves binding to the enzyme's active site, preventing it from catalyzing the conversion of ceramide and phosphatidylcholine into sphingomyelin. Some inhibitors may act competitively by mimicking the enzyme's natural substrates, while others could induce conformational changes that hinder the enzyme's catalytic activity. By inhibiting SMS1, these compounds can lead to a decrease in sphingomyelin production, which may affect cellular processes related to membrane integrity, lipid signaling, and overall cellular function. Research into SMS1 inhibitors provides valuable insights into the regulation of sphingolipid metabolism and highlights the importance of sphingomyelin in various biological processes, including apoptosis, inflammation, and cell differentiation. Understanding the dynamics of SMS1 and its inhibition enhances the knowledge of how lipid biosynthesis influences cellular homeostasis and the intricate balance of membrane composition in response to physiological demands.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide may suppress SMS1 expression by inhibiting the activity of transcription factors directly responsible for the gene's transcription, such as NF-kB, which has been implicated in the control of SMS1 gene expression. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein could reduce SMS1 expression by hindering tyrosine kinase-dependent pathways that, when activated, lead to the upregulation of genes involved in sphingolipid metabolism including SMS1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid may downregulate SMS1 expression by binding to retinoic acid receptors that interact with promoter regions of genes including those governing sphingolipid synthesis, thereby repressing their transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may decrease SMS1 expression by suppressing the activation of transcription factors such as AP-1, which can be involved in the upregulation of SMS1 in response to specific cellular stimuli. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could inhibit SMS1 expression by activating the SIRT1 protein, a deacetylase that can repress the expression of certain genes through histone deacetylation, including those involved in lipid metabolism. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine might decrease SMS1 expression by inhibiting the Hedgehog signaling pathway, which plays a role in the expression of various genes, potentially including those involved in sphingolipid biosynthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may attenuate SMS1 expression by inhibiting the mTOR signaling pathway, which is crucial for the transcription of many genes, possibly including those encoding enzymes like SMS1. | ||||||
SKI II | 312636-16-1 | sc-204286 sc-204286A | 10 mg 50 mg | $96.00 $400.00 | 3 | |
SKI II might lead to a reduction in SMS1 expression by reducing sphingosine-1-phosphate levels, a lipid signaling molecule that can govern the expression of enzymes like SMS1. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone could downregulate SMS1 expression by binding to its nuclear hormone receptors, which may interact with the SMS1 gene promoter region to repress its transcription. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid could reduce SMS1 expression by activating transcriptional repressors or by inhibiting enzymes that facilitate the chromatin remodeling required for SMS1 gene transcription. | ||||||