SPATA2L Activators
SPATA2L, a protein involved in intricate cellular signaling pathways, is subject to regulation and activation by various chemical compounds. Forskolin and Epigallocatechin gallate exemplify this interaction; Forskolin, through elevating cAMP levels, activates PKA, which may phosphorylate proteins interacting with SPATA2L, thereby enhancing its functional activity. Epigallocatechin gallate, a kinase inhibitor, potentially influences kinases that negatively regulate SPATA2L, suggesting that its inhibition could indirectly augment SPATA2L's activity. Similarly, Sphingosine-1-phosphate and Thapsigargin modulate sphingolipid and calcium signaling respectively, indirectly affecting SPATA2L's activity. Sphingosine-1-phosphate alters the cellular environment in a way that favors SPATA2L function, while Thapsigargin's effect on intracellular calcium levels can modify SPATA2L's interaction with calcium-dependent regulatory processes. In addition, LY294002 and Wortmannin, both PI3K inhibitors, by modulating the PI3K/Akt pathway, may shift cellular signaling dynamics in favor of pathways positively regulating SPATA2L, thus indirectly enhancing its activity.
Further exploration into SPATA2L activation reveals the role of MEK and MAPK inhibitors, like U0126 and SB203580. U0126, by inhibiting the MAPK/ERK pathway, could upregulate alternative signaling pathways that positively influence SPATA2L. Similarly, SB203580's inhibition of p38 MAPK can activate signaling routes that favor SPATA2L's function. Staurosporine, a broad-spectrum kinase inhibitor, may lift negative regulatory influences on SPATA2L, leading to its enhanced activity. PMA (Phorbol 12-myristate 13-acetate) also plays a significant role by activating PKC, which can indirectly influence SPATA2L activity through various signaling pathways. A23187 (Calcimycin), by increasing intracellular calcium, activates calcium-dependent pathways that may modify SPATA2L's interactions and activity. Lastly, Genistein, by inhibiting tyrosine kinase, can alter signaling dynamics in a manner that potentially favors SPATA2L activation. Collectively, these compounds, through their targeted effects on cellular signaling, facilitate the enhancement of SPATA2L-mediated functions without the need for upregulating its expression or direct activation
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and subsequently PKA activity. Since PKA can phosphorylate various proteins, it may indirectly enhance SPATA2L activity if SPATA2L is phosphorylated or interacts with proteins regulated by PKA. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels, which could result in the activation of PKA and PKG. This, in turn, could enhance signaling pathways involving SPATA2L. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog which activates protein kinase C (PKC). PKC activation can lead to a cascade of phosphorylation events potentially affecting SPATA2L function if SPATA2L is part of or interacts with proteins in the PKC pathway. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore elevating intracellular Ca2+ concentration, which can activate calcium-dependent protein kinases and potentially enhance the activity of SPATA2L through calcium signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit several protein kinases, potentially altering signaling pathways that may indirectly lead to the enhanced activity of SPATA2L. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of cellular proteins, which could affect SPATA2L activity if SPATA2L is regulated by phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid is a potent inhibitor of protein phosphatases, which may lead to increased phosphorylation and potential activation of SPATA2L. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), which may influence SPATA2L activity if SPATA2L is implicated in the stress response. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine can influence cellular signaling by modulating ion channels and possibly affecting the activity of protein kinases, which could lead to the activation of SPATA2L. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, and by inhibiting PI3K, it could modulate downstream signaling pathways, possibly leading to the activation of SPATA2L if there is a functional link. | ||||||