SPATA12 Inhibitors
SPATA12 inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of SPATA12, a protein that plays a role in spermatogenesis and other reproductive processes. SPATA12, short for Spermatogenesis Associated 12, is part of a larger family of SPATA proteins, which are generally involved in the development and function of male germ cells. Although the precise functions of SPATA12 are not fully understood, it is believed to be involved in the regulation of sperm cell maturation, particularly during the later stages of spermatogenesis when spermatids undergo morphological changes to become mature spermatozoa. By inhibiting SPATA12, researchers can disrupt these processes, providing a valuable tool for studying the specific roles of SPATA12 in reproductive biology and the broader mechanisms governing male fertility.
In research, SPATA12 inhibitors are useful for exploring the molecular mechanisms by which SPATA12 contributes to the complex process of spermatogenesis and the impact of its inhibition on male reproductive function. By blocking SPATA12 activity, scientists can investigate how the disruption affects the development and maturation of sperm cells, particularly focusing on the structural and functional changes that occur during spermiogenesis. This inhibition allows researchers to study the downstream effects on sperm motility, morphology, and overall fertility, providing insights into the role of SPATA12 in ensuring the proper development of functional sperm. Additionally, SPATA12 inhibitors provide a means to explore the interactions between SPATA12 and other proteins involved in spermatogenesis, shedding light on the intricate regulatory networks that coordinate the maturation of male germ cells. Through these studies, the use of SPATA12 inhibitors enhances our understanding of the molecular underpinnings of male reproductive biology, the regulation of spermatogenesis, and the broader implications of these processes for fertility and reproductive health.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound incorporates into DNA and RNA, leading to hypomethylation of DNA, which can silence genes involved in cell differentiation, including SPATA12. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
A histone deacetylase inhibitor that leads to chromatin remodeling and can downregulate gene expression, potentially affecting SPATA12 expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
This histone deacetylase inhibitor can alter chromatin structure and gene expression, which might suppress SPATA12 transcription. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
It intercalates into DNA, inhibiting RNA polymerase and preventing transcription; this could reduce SPATA12 mRNA synthesis. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
It crosslinks DNA, which can inhibit DNA replication and RNA transcription, potentially decreasing SPATA12 expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
A potent inhibitor of RNA polymerase II, it can suppress mRNA synthesis, possibly affecting the production of SPATA12 transcripts. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
This compound inhibits eukaryotic protein synthesis by interfering with the translocation step, which could indirectly lower SPATA12 levels. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR pathway, which is involved in the regulation of protein synthesis and could lead to downregulation of SPATA12 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
It binds to GC-rich DNA sequences, blocking transcription factors and potentially inhibiting SPATA12 gene transcription. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
This topoisomerase I inhibitor prevents DNA re-ligation, leading to DNA damage and potentially downregulating SPATA12 expression. | ||||||