SorLA Inhibitors
SorLA, an acronym for Sortilin-related receptor with A-type repeats, represents a multifunctional sorting receptor that governs crucial cellular processes ranging from protein trafficking to signaling regulation. Positioned predominantly within the endocytic and secretory pathways, SorLA exerts its influence by orchestrating the intracellular trafficking and sorting of a diverse array of ligands, receptors, and cargo proteins. Its role in directing the fate of these molecules is pivotal for maintaining cellular homeostasis and ensuring proper functioning of various physiological processes. Moreover, SorLA's involvement in amyloid precursor protein processing implicates its significance in neurobiology and the pathogenesis of Alzheimer's disease, underscoring its relevance in disease pathology.
Inhibition of SorLA encompasses a diverse array of mechanisms targeting various cellular pathways and processes. Small molecule inhibitors interfere with SorLA function by disrupting key intracellular signaling cascades, such as the PI3K/Akt and MAPK/ERK pathways, which govern SorLA expression and trafficking dynamics. Additionally, compounds that target cellular organelles, such as the Golgi apparatus and lysosomes, impede SorLA sorting and degradation pathways, resulting in altered protein levels and cellular responses. This multifaceted approach to SorLA inhibition not only sheds light on its intricate regulatory mechanisms but also holds promise for unraveling its role in disease states associated with dysregulated SorLA function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic acid inhibits SorLA through the modulation of the PI3K/Akt/mTOR pathway. It disrupts the activation of Akt, leading to decreased phosphorylation of SorLA. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits SorLA by targeting the PI3K/Akt signaling pathway. By irreversibly inhibiting PI3K, it disrupts downstream signaling events that regulate SorLA expression and function. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits SorLA indirectly by disrupting Golgi function and protein trafficking. This leads to impaired sorting of SorLA to its cellular destinations, resulting in decreased protein levels and activity. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine inhibits SorLA by interfering with the Hedgehog signaling pathway. Disruption of Hedgehog signaling alters SorLA expression levels and cellular localization, thereby attenuating its function. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine inhibits SorLA by altering endosomal pH and impairing protein trafficking. This disrupts the recycling of SorLA between endosomes and the trans-Golgi network, leading to reduced protein levels and activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG inhibits SorLA indirectly through its action on Hsp90. Inhibition of Hsp90 leads to proteasomal degradation of client proteins, including SorLA, resulting in decreased protein levels and activity. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin inhibits SorLA by targeting Hsp90 and promoting its degradation. This results in destabilization of SorLA protein, leading to decreased levels and impaired function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits SorLA by blocking lysosomal acidification and impairing protein degradation. This leads to accumulation of SorLA within lysosomes, reducing its availability for cellular functions. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Spautin-1 inhibits SorLA indirectly by promoting the degradation of Vps34 complexes. Disruption of Vps34 complexes impairs endosomal trafficking pathways, leading to altered SorLA localization and reduced protein levels. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits SorLA indirectly by inducing ER stress and disrupting calcium homeostasis. ER stress leads to activation of unfolded protein response pathways, resulting in decreased SorLA expression and function. | ||||||