Sodium Channel Modulators
Items 31 to 40 of 74 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzocaine | 94-09-7 | sc-239305 | 100 g | $29.00 | ||
Benzocaine acts as a sodium channel modulator by selectively binding to the channel's inactivation gate, stabilizing it in a closed state. This interaction disrupts the normal ion flow, leading to a decrease in neuronal excitability. Its unique ability to alter the kinetics of channel recovery from inactivation results in a distinct modulation of action potential propagation. Furthermore, Benzocaine's lipophilic nature enhances its membrane permeability, influencing its interaction dynamics with the channel. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine functions as a sodium channel modulator by preferentially interacting with the channel's voltage-sensing domains, leading to a shift in the activation threshold. This modulation alters the gating kinetics, effectively prolonging the inactivation phase and reducing the frequency of action potentials. Its amphipathic structure facilitates integration into lipid bilayers, enhancing its affinity for the channel and influencing the overall ionic conductance. This unique behavior contributes to its distinct electrophysiological profile. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Triamterene acts as a sodium channel modulator by selectively binding to the channel's inner pore region, influencing ion permeability. Its unique structure allows for specific interactions with charged residues, altering the channel's conformational dynamics. This modulation affects the rate of sodium ion influx, thereby impacting cellular excitability. The compound's hydrophobic characteristics enhance its affinity for lipid environments, further stabilizing its interaction with the channel and modifying its kinetic properties. | ||||||
Kavain (±) | 500-64-1 | sc-201077 sc-201077A | 50 mg 250 mg | $71.00 $294.00 | 2 | |
Kavain (+/-) functions as a sodium channel modulator through its ability to interact with the channel's voltage-sensing domains, leading to alterations in gating mechanisms. Its unique stereochemistry allows for differential binding affinities, influencing the channel's open and closed states. This compound exhibits a distinct capacity to stabilize intermediate conformations, thereby affecting the kinetics of sodium ion flow. Additionally, its lipophilic nature promotes integration into membrane environments, enhancing its modulatory effects. | ||||||
5,5-Diphenylhydantoin sodium salt | 630-93-3 | sc-214337 sc-214337A | 25 g 100 g | $56.00 $128.00 | 2 | |
5,5-Diphenylhydantoin sodium salt acts as a sodium channel modulator by selectively binding to specific sites on the channel, influencing ion permeability and conduction. Its unique structure allows for the stabilization of various channel conformations, which alters the activation and inactivation kinetics. The compound's hydrophobic regions facilitate interactions with lipid membranes, enhancing its modulatory effects on channel dynamics and overall ionic balance. | ||||||
Dihydroouabain | 1183-35-3 | sc-252720 | 50 mg | $459.00 | ||
Dihydroouabain functions as a sodium channel modulator through its ability to interact with the channel's voltage-sensing domains, altering gating mechanisms. Its distinct molecular configuration promotes selective binding, which can influence the channel's open and closed states. This compound exhibits unique reaction kinetics, allowing for rapid modulation of sodium ion flow, while its polar and non-polar regions enhance interactions with surrounding membrane environments, impacting overall channel behavior. | ||||||
5-(N,N-Hexamethylene)amiloride | 1428-95-1 | sc-239021 | 25 mg | $100.00 | 2 | |
5-(N,N-Hexamethylene)amiloride acts as a sodium channel modulator by selectively binding to specific sites within the channel, influencing ion permeability. Its unique structural features facilitate strong interactions with the channel's hydrophobic regions, stabilizing certain conformations. This compound exhibits distinct kinetic properties, allowing for nuanced modulation of sodium ion conductance, while its amphipathic nature enhances its affinity for lipid bilayers, affecting channel dynamics. | ||||||
Mexiletine hydrochloride (≥99%) | 5370-01-4 | sc-203633 | 50 mg | $77.00 | ||
Mexiletine hydrochloride functions as a sodium channel modulator by engaging with the channel's voltage-sensing domains, altering gating mechanisms. Its unique aromatic structure allows for effective π-π stacking interactions with channel residues, enhancing binding affinity. The compound exhibits rapid kinetics, enabling swift modulation of sodium ion flow. Additionally, its hydrophilic and lipophilic balance promotes effective integration into membrane environments, influencing channel behavior and stability. | ||||||
Proxymetacaine Hydrochloride | 5875-06-9 | sc-205820 sc-205820A | 100 mg 250 mg | $80.00 $167.00 | ||
Proxymetacaine Hydrochloride acts as a sodium channel modulator by selectively binding to the channel's inactivation gate, disrupting the normal ion flow. Its unique aliphatic and aromatic components facilitate strong hydrophobic interactions with channel proteins, enhancing its affinity. The compound's rapid association and dissociation kinetics allow for precise modulation of channel activity, while its amphipathic nature aids in membrane penetration, impacting channel dynamics and function. | ||||||
Quinidine sulfate dihydrate | 6591-63-5 | sc-205967 | 5 g | $67.00 | ||
Quinidine sulfate dihydrate functions as a sodium channel modulator by stabilizing the inactivated state of the channel, effectively altering ion permeability. Its unique stereochemistry promotes specific interactions with channel residues, influencing gating kinetics. The compound exhibits a dual mechanism, where it can both block and enhance channel activity depending on the concentration. Additionally, its solubility characteristics facilitate effective distribution within lipid membranes, impacting overall channel behavior. | ||||||