Molecular structure of Kavain (±), CAS Number: 500-64-1
Kavain (±) (CAS 500-64-1)
See product citations (2)
Application:
Kavain (±) is a biologically active component of kava that blocks various cationic voltage-gated channels
CAS Number:
500-64-1
Purity:
98%
Molecular Weight:
230.3
Molecular Formula:
C14H14O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Kavain (±), a lipophilic kavapyrone, has been originally extracted from Piper methysticum. This compound has been shown to significantly antagonize dopamine depletion in murine striatal neurons. Additional studies report that Kavain (±) impairs vascular smooth muscle contraction via inhibition of Ca+ channels, causing relaxation in precontracted murine ileum, airways, and aortic rings. Furthermore, at high concentrations, this agent has been noted to display neurotoxic characteristics.
Kavain (±) (CAS 500-64-1) References
- Effects of (+/-)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats. | Schirrmacher, K., et al. 1999. Eur Neuropsychopharmacol. 9: 171-6. PMID: 10082244
- Kavain inhibits murine airway smooth muscle contraction. | Martin, HB., et al. 2000. Planta Med. 66: 601-6. PMID: 11105562
- Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease. | Schmidt, N. and Ferger, B. 2001. Synapse. 40: 47-54. PMID: 11170221
- Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus. | Mulholland, PJ. and Prendergast, MA. 2002. Brain Res. 945: 106-13. PMID: 12113957
- Kava-kava and anxiety: growing knowledge about the efficacy and safety. | Bilia, AR., et al. 2002. Life Sci. 70: 2581-97. PMID: 12269386
- Kavain attenuates vascular contractility through inhibition of calcium channels. | Martin, HB., et al. 2002. Planta Med. 68: 784-9. PMID: 12357387
- (+/-)-Kavain inhibits veratridine-activated voltage-dependent Na(+)-channels in synaptosomes prepared from rat cerebral cortex. | Gleitz, J., et al. 1995. Neuropharmacology. 34: 1133-8. PMID: 8532183
- Anticonvulsive action of (+/-)-kavain estimated from its properties on stimulated synaptosomes and Na+ channel receptor sites. | Gleitz, J., et al. 1996. Eur J Pharmacol. 315: 89-97. PMID: 8960869
- Relaxation of evoked contractile activity of isolated guinea-pig ileum by (+/-)-kavain. | Seitz, U., et al. 1997. Planta Med. 63: 303-6. PMID: 9270372
- Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. | Magura, EI., et al. 1997. Neuroscience. 81: 345-51. PMID: 9300426
- In vivo effects of the kavapyrones (+)-dihydromethysticin and (+/-)-kavain on dopamine, 3,4-dihydroxyphenylacetic acid, serotonin and 5-hydroxyindoleacetic acid levels in striatal and cortical brain regions. | Boonen, G., et al. 1998. Planta Med. 64: 507-10. PMID: 9741294
- The influence of (+/-)-kavain on population spikes and long-term potentiation in guinea pig hippocampal slices. | Langosch, JM., et al. 1998. Comp Biochem Physiol A Mol Integr Physiol. 120: 545-9. PMID: 9787833
Inhibitor of:
gremlin-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Kavain (±), 50 mg | sc-201077 | 50 mg | $71.00 | |||
Kavain (±), 250 mg | sc-201077A | 250 mg | $294.00 |