Molecular structure of Dihydroouabain, CAS Number: 1183-35-3
Dihydroouabain (CAS 1183-35-3)
Alternate Names:
3-[(6-Deoxyhexopyranosyl)oxy]-1,5,11,14,19-pentahydroxycardanolide
CAS Number:
1183-35-3
Molecular Weight:
586.67
Molecular Formula:
C29H46O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dihydroouabain is a cardiac glycoside and an inhibitor of the sodium-potassium pump. By inhibiting the guanine nucleotide-binding (G) protein, this compound effectively modulates the activity of adenylate cyclase and phospholipase C enzymes. Consequently, the production of cyclic AMP and diacylglycerol is significantly reduced.
Dihydroouabain (CAS 1183-35-3) References
- Two biologically active isomers of dihydroouabain isolated from a commercial preparation. | Qazzaz, HM., et al. 1999. Biochim Biophys Acta. 1472: 486-97. PMID: 10564763
- Effects of low concentration of dihydroouabain on intracellular calcium in guinea pig ventricular myocytes. | Yin, JX., et al. 2002. Sheng Li Xue Bao. 54: 385-9. PMID: 12399817
- The kinetics of the inhibition by dihydroouabain of the sodium pump current in single rabbit cardiac Purkinje cells. | Bielen, FV., et al. 1992. Naunyn Schmiedebergs Arch Pharmacol. 345: 100-7. PMID: 1311424
- Dihydroouabain, a reversible inhibitor of the sodium pump in frog skin. | Cox, TC. and Woods, RE. 1987. Pflugers Arch. 409: 323-7. PMID: 2442703
- Inhibition of Na-K pump current in guinea pig ventricular myocytes by dihydroouabain occurs at high- and low-affinity sites. | Mogul, DJ., et al. 1989. Circ Res. 64: 1063-9. PMID: 2541941
- Dihydroouabain, a novel radiosensitizer for cervical cancer identified by automated high-throughput screening. | Li, Z., et al. 2020. Radiother Oncol. 148: 21-29. PMID: 32311597
- Independence of the positive inotropic effect of ouabain from the inhibition of the heart Na+/K+ pump. | Godfraind, T. and Ghysel-Burton, J. 1980. Proc Natl Acad Sci U S A. 77: 3067-9. PMID: 6248887
- Dihydroouabain is an antagonist of ouabain inotropic action. | Godfraind, T., et al. 1982. Nature. 299: 824-6. PMID: 6290892
- A comparison of the effects of ouabain, dihydroouabain and 3 alpha-methyldigitoxigenin glucoside on guinea pig left atria. | Brown, L. and Erdmann, E. 1984. Arzneimittelforschung. 34: 204-8. PMID: 6326779
- The inotropic effect of ouabain and its antagonism by dihydroouabain in rat isolated atria and ventricles in relation to specific binding sites. | Finet, M., et al. 1983. Br J Pharmacol. 80: 751-9. PMID: 6571229
- Different effects of isoproterenol and dihydroouabain on cardiac Ca2+ transients. | Hotta, Y., et al. 1995. Eur J Pharmacol. 282: 121-30. PMID: 7498266
- Comparison of the inhibitory effect of ouabain and dihydroouabain on the Na(+)-K+ ATPase from frog skin. | Nichols, JR. and Maldonado, HS. 1993. Gen Pharmacol. 24: 349-52. PMID: 8387052
- A comparative study of effects of isoproterenol and dihydroouabain on calcium transients and contraction in cultured rat ventricular cells. | Tatsukawa, Y., et al. 1993. J Mol Cell Cardiol. 25: 707-20. PMID: 8411196
Activator of:
Na+/K+-ATPase α2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydroouabain, 50 mg | sc-252720 | 50 mg | $468.00 |