SOCS-5 Activators
SOCS-5 (Suppressor of Cytokine Signaling 5) activators belong to a class of small molecules or compounds designed to modulate the activity of the SOCS-5 protein. SOCS-5 is a member of the suppressor of cytokine signaling (SOCS) family of proteins, which play a crucial role in regulating the immune and inflammatory responses in mammals. SOCS proteins act as negative feedback regulators of the JAK-STAT signaling pathway, a fundamental pathway for transmitting extracellular signals to the cell nucleus. These proteins are characterized by their SH2 (Src homology 2) and SOCS box domains. Specifically, SOCS-5 contains an SH2 domain, enabling it to bind to phosphorylated tyrosine residues on specific cytokine receptors or associated signaling proteins.
SOCS-5 activators are designed to enhance the activity of SOCS-5, which in turn influences the extent and duration of the immune response. By promoting SOCS-5 function, these activators can fine-tune the immune system's response to various stimuli, including cytokines. Such modulation can have wide-ranging implications for understanding and controlling immune responses in various physiological and pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK inhibitor that indirectly activates SOCS-5, contributing to the regulation of cytokine signaling in myelofibrosis and polycythemia vera. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Natural compound with anti-inflammatory properties, potentially indirectly increasing SOCS-5 expression and activating cytokine signaling. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor studied in the research of multiple myeloma, with potential indirect effects on increasing SOCS-5 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor with immunosuppressive applications, indirectly activating SOCS-5 and modulating cytokine signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
Inhibitor of p38 MAPK involved in inflammatory responses, potentially increasing SOCS-5 and its downstream pathways indirectly. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
TGF-β receptor inhibitor blocking TGF-β signaling, which can indirectly activate SOCS-5 regulation and immune responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibitor of PI3K in the PI3K-AKT signaling pathway, potentially indirectly increasing SOCS-5 and its role in cytokine signaling. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
HDAC inhibitor used in epilepsy and bipolar disorder treatment, with potential indirect effects on increasing SOCS-5 and its role in cytokine control. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Corticosteroid increasing cytokine signaling, potentially indirectly activating SOCS-5 in immune responses. | ||||||