SOCS-5 Antibody (31-L): sc-100858

SOCS-5 Antibody (31-L) is a mouse monoclonal IgG1 kappa light chain antibody that detects SOCS-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOCS-5 antibody (31-L) is available as non-conjugated format. SOCS-5 protein plays a crucial role in the negative regulation of cytokine signaling, which is essential for maintaining immune homeostasis and preventing excessive inflammatory responses. Located primarily in the cytoplasm, SOCS-5 interacts with various signaling pathways, including those activated by interleukin-6, thereby modulating STAT3 transcription factor activity. This regulation is vital because dysregulation of SOCS-5 can lead to chronic inflammation and autoimmune diseases. The SOCS family, which includes SOCS-1, SOCS-2, and SOCS-3, is characterized by a central SH2 domain and a unique SOCS box that facilitates protein-protein interactions, further underscoring SOCS-5′s importance in cellular signaling networks. With proven detection capabilities across multiple species and applications, SOCS-5 monoclonal antibody (31-L) serves as an invaluable tool for researchers studying cytokine signaling and its implications in health and disease.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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SOCS-5 Antibody (31-L) References:

1. Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis.  |  Arakawa, S., et al. 2004. Clin Exp Immunol. 135: 505-10. PMID: 15008986
2. Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.  |  Nicholson, SE., et al. 2005. Proc Natl Acad Sci U S A. 102: 2328-33. PMID: 15695332
3. Overexpression of suppressor of cytokine signalling-5 augments eosinophilic airway inflammation in mice.  |  Ohshima, M., et al. 2007. Clin Exp Allergy. 37: 735-42. PMID: 17456221
4. Fms-like tyrosine kinase 3 ligand decreases T helper type 17 cells and suppressors of cytokine signaling proteins in the lung of house dust mite-sensitized and -challenged mice.  |  McGee, HS., et al. 2010. Am J Respir Cell Mol Biol. 43: 520-9. PMID: 19933379
5. Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling.  |  Kedzierski, L., et al. 2017. Elife. 6: PMID: 28195529
6. Suppressors of cytokine signaling in tuberculosis.  |  Lee, SW., et al. 2017. PLoS One. 12: e0176377. PMID: 28430824
7. Effects of valproic acid on SOCS-1, SOCS-2, SOCS-3, SOCS-5, SOCS6, and SOCS-7 gene expression and cell growth inhibition in colon carcinoma.  |  Sanaei, M., et al. 2022. Gastroenterol Hepatol Bed Bench. 15: 39-44. PMID: 35611249
8. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.  |  Yoshimura, A., et al. 1995. EMBO J. 14: 2816-26. PMID: 7796808
9. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation.  |  Matsumoto, A., et al. 1997. Blood. 89: 3148-54. PMID: 9129017
10. A family of cytokine-inducible inhibitors of signalling.  |  Starr, R., et al. 1997. Nature. 387: 917-21. PMID: 9202125
11. Twenty proteins containing a C-terminal SOCS box form five structural classes.  |  Hilton, DJ., et al. 1998. Proc Natl Acad Sci U S A. 95: 114-9. PMID: 9419338
12. The SOCS proteins: a new family of negative regulators of signal transduction.  |  Nicholson, SE. and Hilton, DJ. 1998. J Leukoc Biol. 63: 665-8. PMID: 9620657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SOCS-5 Antibody (31-L) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-SOCS-5 Antibody (31-L) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SOCS-5 Antibody (31-L) Specifications

Alternate Product Name: SOCS-5

Product Clone Name: 31-L

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-110

Epitope Target: SOCS-5

Epitope Species: human

Product Reactivity/Detection: SOCS-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for SOCS-5 Antibody (31-L): N/A