Date published: 2026-3-17

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SOCS-4 Inhibitors

SOCS-4 inhibitors belong to a distinctive class of chemical compounds that primarily target the Suppressors of Cytokine Signaling 4 (SOCS-4) proteins within the cellular signaling pathways. The SOCS family of proteins plays a crucial role in regulating the immune system and maintaining homeostasis by controlling the intensity and duration of cytokine signals. SOCS-4, specifically, is involved in modulating various cellular responses, including immune reactions and inflammatory processes. The inhibitors designed for SOCS-4 typically exert their effects by disrupting the normal functioning of this protein, thereby influencing downstream signaling cascades.

SOCS-4 inhibitors are characterized by specific structural motifs that enable them to interact selectively with the SOCS-4 protein. These inhibitors often feature binding pockets and functional groups that allow them to competitively bind to the active sites of SOCS-4, preventing its interaction with target proteins or substrates. By interfering with the normal regulatory function of SOCS-4, these inhibitors have the potential to modulate immune responses and inflammatory pathways, making them intriguing candidates for further research in understanding cellular signaling mechanisms. The development and exploration of SOCS-4 inhibitors contribute significantly to the broader field of chemical biology, offering insights into the intricacies of immune regulation and providing a foundation for potential applications in modulating cellular responses for various research purposes.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tyrphostin B42

133550-30-8sc-3556
5 mg
$26.00
4
(1)

JAK2 inhibitor that can reduce STAT activation and thus indirectly affect SOCS4 function.

Stat3 Inhibitor III, WP1066

857064-38-1sc-203282
10 mg
$132.00
72
(1)

Targets JAK2 and inhibits STAT3 phosphorylation, possibly limiting SOCS4-related feedback loops.

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$251.00
$500.00
$547.00
16
(1)

JAK1 and JAK2 inhibitor, can downregulate STAT signaling upstream of SOCS4.

Baricitinib

1187594-09-7sc-364730
sc-364730A
5 mg
25 mg
$200.00
$664.00
(1)

Inhibits JAK1 and JAK2, potentially altering the pathway that includes SOCS4.

Cucurbitacin I

2222-07-3sc-203010
1 mg
$250.00
9
(1)

Inhibits STAT3 phosphorylation, thereby may influence SOCS4 indirectly.

Stat3 Inhibitor VI, S3I-201

501919-59-1sc-204304
10 mg
$151.00
104
(1)

Inhibits STAT3 dimerization, potentially impacting SOCS4's modulation of the pathway.

Pimozide

2062-78-4sc-203662
100 mg
$104.00
3
(1)

STAT5 inhibitor that could affect pathways regulating SOCS4.

JAK Inhibitor I

457081-03-7sc-204021
sc-204021A
500 µg
1 mg
$156.00
$339.00
59
(1)

JAK inhibitor that can alter STAT phosphorylation and thus impact SOCS4 dynamics.