SOCS-4 Antibody (F-1): sc-518223
- SOCS-4 Antibody (F-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 233-258 of SOCS-4 of human origin
- recommended for detection of SOCS-4 of human origin by WB, IP, IF and ELISA
- Anti-SOCS-4 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SOCS-4 Antibody (F-1) for WB applications. These reagents are now offered in bundles with SOCS-4 Antibody (F-1) (see ordering information below).
SOCS-4 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects human SOCS-4 by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SOCS-4 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SOCS-4, also known as suppressor of cytokine signaling 4 or SOCS7, is a 440 amino acid protein characterized by the presence of one SH2 domain and one SOCS box domain, which is crucial for interaction with the Elongin B/C complex. This interaction is significant as SOCS-4 facilitates a role in the ubiquitin-proteasome pathway, exhibiting E3 ubiquitin-protein ligase activity, mediating ubiquitination and subsequent proteasomal degradation of target proteins. The regulation of protein degradation is vital for maintaining cellular homeostasis and modulating signaling pathways, particularly in response to cytokine signaling, which can influence various physiological processes and disease states. Anti-SOCS-4 antibody (F-1) enables researchers to gain insights into the intricate mechanisms of cytokine signaling and the role of SOCS proteins in cellular regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SOCS-4 Antibody (F-1) References:
- The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. | Zhang, JG., et al. 1999. Proc Natl Acad Sci U S A. 96: 2071-6. PMID: 10051596
- The suppressors of cytokine signalling (SOCS). | Kile, BT. and Alexander, WS. 2001. Cell Mol Life Sci. 58: 1627-35. PMID: 11706989
- The SOCS box: a tale of destruction and degradation. | Kile, BT., et al. 2002. Trends Biochem Sci. 27: 235-41. PMID: 12076535
- Suppressors of cytokine signalling: SOCS. | Larsen, L. and Röpke, C. 2002. APMIS. 110: 833-44. PMID: 12645661
- Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. | Kario, E., et al. 2005. J Biol Chem. 280: 7038-48. PMID: 15590694
- Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. | Bullock, AN., et al. 2007. Structure. 15: 1493-504. PMID: 17997974
- The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. | Kamura, T., et al. 1998. Genes Dev. 12: 3872-81. PMID: 9869640
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SOCS-4 Antibody (F-1) | sc-518223 | 200 µg/ml | $316.00 | |||
SOCS-4 Antibody (F-1): m-IgG Fc BP-HRP Bundle | sc-551383 | 200 µg Ab; 10 µg BP | $354.00 | |||
SOCS-4 Antibody (F-1): m-IgG1 BP-HRP Bundle | sc-551382 | 200 µg Ab; 20 µg BP | $354.00 | |||
SOCS-4 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-551384 | 200 µg Ab; 40 µg BP | $354.00 | |||
SOCS-4 Antibody (F-1) AC | sc-518223 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SOCS-4 Antibody (F-1) HRP | sc-518223 HRP | 200 µg/ml | $316.00 | |||
SOCS-4 Antibody (F-1) FITC | sc-518223 FITC | 200 µg/ml | $330.00 | |||
SOCS-4 Antibody (F-1) PE | sc-518223 PE | 200 µg/ml | $343.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 488 | sc-518223 AF488 | 200 µg/ml | $357.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 546 | sc-518223 AF546 | 200 µg/ml | $357.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 594 | sc-518223 AF594 | 200 µg/ml | $357.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 647 | sc-518223 AF647 | 200 µg/ml | $357.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 680 | sc-518223 AF680 | 200 µg/ml | $357.00 | |||
SOCS-4 Antibody (F-1) Alexa Fluor® 790 | sc-518223 AF790 | 200 µg/ml | $357.00 |