SNAT5 Activators
SNAT5 Activators encompass a range of chemical compounds that directly or indirectly upregulate the activity of the Sodium-coupled Neutral Amino Acid Transporter 5. The essential role of sodium ions is highlighted by their creation of an electrochemical gradient, which is a fundamental mechanism that SNAT5 utilizes to transport amino acids across the cell membrane. Similarly, the presence of specific amino acids such as leucine in the extracellular environment serves as a substrate that SNAT5 can effectively transport, thereby increasing its activity. Hormonal influences, such as insulin, enhance the PI3K/Akt pathway, promoting the translocation of SNAT5 to the plasma membrane, which is a critical step in augmenting its transport capacity. Phorbol esters like PMA activate PKC, which may enhance the surface expression of SNAT5 by modulating the cellular trafficking machinery.
SNAT5 activators comprise a diverse array of chemical entities that serve to enhance the functional activity of Sodium-coupled Neutral Amino Acid Transporter 5 through distinct biochemical pathways and cellular processes. Sodium ions, fundamental to SNAT5's mechanism, heighten its activity by establishing the necessary electrochemical gradient for amino acid transport. Leucine, as a transported substrate, directly promotes transporter engagement, while insulin, signaling through the PI3K/Akt pathway, increases SNAT5's translocation to the plasma membrane, consequently amplifying its transport capacity. PMA, through PKC activation, potentially escalates the membrane localization of SNAT5, influencing its transport efficacy. Similarly, dibutyryl-cAMP and Ionomycin, by activating PKA and raising intracellular calcium respectively, may enhance SNAT5 activity by promoting its cellular trafficking and membrane insertion. EGF, by triggering downstream signaling via the EGFR, can indirectly increase SNAT5's surface expression, as can the mTOR inhibitor rapamycin, which upregulates amino acid transporters as a compensatory mechanism during nutrient scarcity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $61.00 | ||
Leucine is one of the amino acids that SNAT5 is known to transport. By increasing the extracellular concentration of leucine, SNAT5 activity can be indirectly increased due to substrate availability. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin can stimulate amino acid uptake by activating the PI3K/Akt signaling pathway, which has been shown to increase the surface expression and activity of amino acid transporters including SNAT5. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the phosphorylation and activation of trafficking proteins that control the cell surface expression of SNAT5, thereby enhancing its functional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, can mimic cAMP’s effect by activating PKA, which can phosphorylate and influence the cellular trafficking machinery, potentially increasing the membrane localization and activity of SNAT5. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can stimulate the exocytosis of intracellular vesicles containing SNAT5, resulting in increased surface expression and activity of the transporter. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibition of mTOR, a sensor of cellular nutrient and energy status, can upregulate amino acid transporters including SNAT5 as a compensatory response to perceived nutrient scarcity. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
TUDCA is a bile acid that can influence cellular stress pathways, and has been implicated in the stabilization of membrane proteins, potentially enhancing the stability and activity of SNAT5 on the cell surface. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can differentiate cells and influence gene expression, which may include upregulation of transporters like SNAT5 as part of cellular maturation and function enhancement. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium ions can influence various signaling pathways including GSK-3, which might modulate the trafficking and stability of membrane proteins including SNAT5, thereby potentially enhancing its activity. | ||||||