SMOC-2 Activators
SMOC-2 activators are a category of chemical compounds that influence the activity of the protein SMOC-2, which stands for SPARC-related modular calcium-binding protein 2. SMOC-2 is part of the matricellular protein family, playing a diverse role in cell-matrix interactions, angiogenesis, and tissue remodeling. The protein is known to be involved in various cellular processes, including the regulation of cell adhesion, migration, and proliferation, partly through its modulation of growth factor signaling pathways.
The activation of SMOC-2 can be achieved through either direct or indirect mechanisms. Direct activators bind to the protein and induce conformational changes that enhance its functional activity. These changes affect the protein's ability to interact with other cell-matrix components or with receptors on the cell surface, thereby promoting its role in cellular processes. For example, a direct activator could stabilize the interaction between SMOC-2 and growth factors, enhancing its ability to modulate signaling pathways that are critical for angiogenesis or wound healing. Indirect activators, on the other hand, may influence the expression levels of SMOC-2 or affect its post-translational modifications. These could include compounds that upregulate the transcription of the SMOC-2 gene, leading to increased protein synthesis. Alternatively, they could be involved in modifying the intracellular signaling pathways that affect the stability or localization of the SMOC-2 protein, thus indirectly enhancing its activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing the production of cyclic AMP. Elevated levels of cAMP can stimulate protein kinase A (PKA), which is known to phosphorylate and activate SMOC-2. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine binds to the beta-adrenergic receptor, increasing cAMP production. This increase leads to the activation of PKA, which can phosphorylate and enhance the functional activity of SMOC-2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels. The elevated cAMP levels stimulate PKA, which can phosphorylate and activate SMOC-2. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine binds to the A2a adenosine receptor, stimulating the production of cAMP. Increased cAMP activates PKA, leading to the phosphorylation and activation of SMOC-2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4, preventing the breakdown of cAMP. Elevated levels of cAMP stimulate PKA, which can phosphorylate and activate SMOC-2. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine binds to the D1 receptor, increasing the levels of cAMP. The subsequent activation of PKA leads to the phosphorylation and activation of SMOC-2. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
PGE2 binds to the EP2 and EP4 receptors, leading to an increase in cAMP production. The elevated cAMP levels activate PKA, which can phosphorylate and activate SMOC-2. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective phosphodiesterase inhibitor which increases cAMP levels. Higher levels of cAMP stimulate PKA, leading to the phosphorylation and activation of SMOC-2. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $94.00 $283.00 $988.00 | 7 | |
Histamine binds to the H2 receptor, increasing the production of cAMP. Elevated cAMP levels stimulate PKA, which can phosphorylate and activate SMOC-2. | ||||||
Salmeterol | 89365-50-4 | sc-224277 sc-224277A | 10 mg 50 mg | $186.00 $562.00 | 1 | |
Salmeterol is a long-acting beta2-adrenergic receptor agonist that increases cAMP production. The elevated cAMP levels stimulate PKA, which can phosphorylate and activate SMOC-2. | ||||||