SLC5A12 Inhibitors
SLC5A12 inhibitors belong to a specific chemical class that plays a crucial role in modulating cellular transport processes. The SLC5A12 gene encodes a member of the sodium-dependent glucose transporters (SGLTs) family, which are integral membrane proteins responsible for the transport of glucose and other solutes across cell membranes. Inhibitors targeting SLC5A12 act by disrupting the function of this particular sodium-dependent glucose transporter, thereby influencing the cellular uptake of glucose and other substrates. These inhibitors are designed to bind selectively to the SLC5A12 protein, impeding its normal transport activity.
SLC5A12 inhibitors stems from the recognition of the pivotal role played by sodium-dependent glucose transporters in maintaining glucose homeostasis within cells. By specifically inhibiting SLC5A12, researchers aim to elucidate the intricate mechanisms underlying glucose transport and its regulatory pathways. This class of inhibitors may prove valuable in understanding the physiological significance of SLC5A12 in various tissues and organs. The chemical modifications and structural features of SLC5A12 inhibitors are meticulously designed to interact with the target protein, paving the way for a deeper understanding of the molecular processes involved in cellular glucose transport.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $63.00 $250.00 | 13 | |
Phloretin is a dihydrochalcone, a type of natural phenol. It inhibits various transport proteins and can disrupt the sodium gradient, indirectly affecting SLC5A12 function. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is a cardenolide that inhibits Na⁺/K⁺-ATPase. This inhibition can alter sodium homeostasis, indirectly modulating SLC5A12 activity. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a pyrazine diuretic compound which inhibits sodium reabsorption. By altering sodium gradients, it can indirectly influence SLC5A12. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $107.00 $157.00 $449.00 | 6 | |
Nitrendipine is a dihydropyridine calcium channel blocker that can influence sodium-calcium exchange, potentially altering SLC5A12 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a diterpene that activates adenylate cyclase, influencing cellular cAMP levels which could indirectly modulate SLC5A12 activity. | ||||||
Triamterene | 396-01-0 | sc-213103A sc-213103 | 1 g 5 g | $22.00 $53.00 | ||
Triamterene is a potassium-sparing diuretic, which inhibits sodium reabsorption and could indirectly affect SLC5A12 transport activity. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is a polyether antibiotic that alters sodium transport across membranes, potentially influencing SLC5A12 indirectly. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin, a cardenolide like ouabain, inhibits Na⁺/K⁺-ATPase, altering intracellular sodium levels and possibly influencing SLC5A12 indirectly. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Ethacrynic acid is a phenoxyacetic acid derivative that can inhibit sodium reabsorption in the kidneys, potentially affecting SLC5A12 indirectly. | ||||||