SLC4A7 Activators
SLC4A7 Activators belong to a broad range of chemical classes, including simple inorganic salts like sodium bicarbonate and sodium chloride, alkaloids like forskolin, and synthetic compounds like DIDS. The primary functional mechanism shared by these chemicals is their ability to modulate the activity of SLC4A7 indirectly, either by altering the intracellular environment or by competing for binding sites on the protein.
Several of these chemicals exploit the sensitivity of SLC4A7 to changes in the ionic composition of the intracellular and extracellular environments. Sodium bicarbonate and sodium chloride, for instance, act by altering the substrate availability or the osmotic gradient across the cell membrane. Others, like DIDS and clonidine, influence SLC4A7 activity through more complex mechanisms involving competitive antagonism or modulation of signal transduction pathways. Despite their diverse structures and mechanisms of action, all these chemicals ultimately impact the transportation of bicarbonate ions across cell membranes, a crucial process in maintaining cellular homeostasis and pH balance. The study of SLC4A7 activators can thus yield important insights into the regulation of bicarbonate transport and its role in cellular physiology.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic acid is a compound that activates SLC4A7 by modulating the calcium-activated chloride channel pathway. It binds to the calcium-activated chloride channels, leading to their activation and subsequent activation of SLC4A7, resulting in increased chloride transport. | ||||||
Ethacrynic acid | 58-54-8 | sc-257424 sc-257424A | 1 g 5 g | $49.00 $229.00 | 5 | |
Ethacrynic acid is known to activate SLC4A7 by inhibiting the sodium-potassium-chloride cotransporter pathway. By inhibiting this cotransporter, ethacrynic acid indirectly activates SLC4A7, as it acts as a compensatory mechanism to maintain chloride transport. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) activates SLC4A7 through the prostaglandin signaling pathway. It binds to specific prostaglandin receptors, triggering a signaling cascade that leads to the activation of SLC4A7 and increased bicarbonate transport. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates SLC4A7 by stimulating the adenylate cyclase pathway. It increases the production of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA then phosphorylates SLC4A7, leading to its activation and increased bicarbonate transport. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain activates SLC4A7 by inhibiting the sodium-potassium ATPase pathway. By inhibiting this ATPase, ouabain indirectly activates SLC4A7, as it disrupts the sodium gradient, leading to increased bicarbonate transport. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride activates SLC4A7 by inhibiting the epithelial sodium channel pathway. By inhibiting this channel, amiloride indirectly activates SLC4A7, as it disrupts the sodium gradient, leading to increased bicarbonate transport. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin activates SLC4A7 through the MAPK/ERK signaling pathway. It activates MAPK/ERK, which then phosphorylates SLC4A7, leading to its activation and increased bicarbonate transport. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SLC4A7 by modulating the SIRT1/AMPK pathway. It activates SIRT1, which in turn activates AMPK. AMPK then phosphorylates SLC4A7, leading to its activation and increased bicarbonate transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein activates SLC4A7 through the tyrosine kinase signaling pathway. It inhibits tyrosine kinase enzymes, leading to the activation of SLC4A7 and increased bicarbonate transport. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $47.00 $100.00 | 1 | |
Taurine activates SLC4A7 by modulating the calcium signaling pathway. It enhances intracellular calcium levels, which then activates SLC4A7 and increases bicarbonate transport. | ||||||