SLC41A1 Inhibitors
SLC41A1 inhibitors encompass a group of compounds that indirectly affect the function of the SLC41A1 protein. SLC41A1 is integral to the regulation of magnesium ion transport across cell membranes. The indirect inhibitors listed do not bind to SLC41A1 directly; instead, they influence the protein's activity through modulation of the cellular ionic environment or through the regulation of other ion transporters and channels that maintain the homeostasis of magnesium, which is the primary ion transported by SLC41A1. These compounds include various diuretics, calcium channel blockers, and other agents that alter cellular ion concentrations. For example, loop diuretics such as furosemide and bumetanide increase the renal excretion of magnesium, potentially decreasing intracellular magnesium levels and, as a consequence, affecting the transport activity of SLC41A1.
Moreover, the activity of SLC41A1 can be influenced by the cellular signaling pathways that regulate ion channel and transporter function. Compounds like SKF-96365 and 2-APB affect calcium signaling, which is deeply intertwined with magnesium homeostasis. By altering the signaling pathways or the function of other ion channels and transporters, these compounds create a cellular environment that can influence the function of SLC41A1. This indirect mode of action reflects the intricate network of cellular ion regulation, where the modulation of one ion's homeostasis can have cascading effects on the transport and balance of others, including magnesium.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is known to inhibit sodium channels and Na+/H+ exchangers. By affecting sodium homeostasis, it can secondarily alter intracellular magnesium concentrations, which could interfere with SLC41A1's transport activity. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is an inhibitor of the Na+/K+-ATPase pump. Disruption of this pump's activity can lead to a dysregulation of intracellular ions, including magnesium, which may affect the function of SLC41A1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker. By altering calcium dynamics in the cell, it can influence cellular processes that are also sensitive to magnesium availability, thereby potentially affecting SLC41A1 activity. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is another calcium channel blocker with effects similar to verapamil. It can alter the cellular ionic environment, potentially impacting magnesium homeostasis and SLC41A1 function. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is a calcium channel antagonist that can affect the transport of calcium and indirectly influence magnesium levels within the cell, potentially affecting SLC41A1-mediated transport. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SKF-96365 is an inhibitor of receptor-mediated calcium entry, as well as other cation channels. By modulating calcium and possibly magnesium levels, it can alter the activity of SLC41A1. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is known to block IP3 receptors and TRP channels, affecting calcium signaling. This disruption can have downstream effects on magnesium handling and potentially influence SLC41A1 activity. | ||||||
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $45.00 $197.00 $351.00 $759.00 | 1 | |
Carbenoxolone is a gap junction inhibitor that can affect intercellular communication. Altered cellular signaling can lead to changes in ionic homeostasis, including that of magnesium, thereby potentially impacting SLC41A1 function. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide is a loop diuretic that can cause increased excretion of various ions, including magnesium. This can affect overall magnesium balance and potentially the activity of SLC41A1 in maintaining intracellular magnesium levels. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide is a thiazide diuretic which can lead to decreased cellular magnesium levels by increasing magnesium excretion, potentially affecting SLC41A1's role in magnesium homeostasis. | ||||||