SLC39A11 Activators
Zinc sulfate provides a direct source of zinc ions, augmenting intracellular concentrations, which could trigger a homeostatic upregulation of SLC39A11 to rebalance zinc levels. 1-Hydroxypyridine-2-thione zinc salt, as an ionophore, enhances the cellular influx of zinc, leading to a similar compensatory response in SLC39A11 activity. Histidine, an amino acid with zinc-chelating properties, when bound to zinc, can signal for an increased expression of zinc transporters, thus potentially boosting SLC39A11 function. Compounds such as nicotinamide, a form of vitamin B3, and retinoic acid, a derivative of vitamin A, are known to modulate gene expression. These compounds can indirectly influence the expression of SLC39A11 by altering the cellular metabolic and redox states or by regulating differentiation and growth processes that necessitate zinc transport. Polyphenolic compounds like epigallocatechin gallate (EGCG) and resveratrol, due to their roles in cellular signaling and oxidative stress modulation, could also lead to an upregulation of zinc transporter proteins including SLC39A11 to maintain cellular zinc equilibrium.
Lithium chloride impacts a variety of signaling pathways and can alter gene expression profiles, which may include those related to metal ion homeostasis and thus affect SLC39A11 expression. Dexamethasone, through its effects on inflammation and cellular stress responses, could also mediate the expression of zinc transporters. Chloroquine, by altering lysosomal function and autophagy, may necessitate the regulation of metal ion transporters to adjust to changes in metal ion storage and distribution, potentially affecting SLC39A11. Flavonoids like quercetin and endocrine-disrupting compounds such as bisphenol A are implicated in the modulation of cellular signaling and metal ion balance, which can lead to an adaptive increase in the activity of zinc transporters, including SLC39A11.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate is a source of zinc ions, which can upregulate the expression of zinc transporter proteins, including SLC39A11, as the cell attempts to restore zinc homeostasis. | ||||||
L-Histidine | 71-00-1 | sc-394101 sc-394101A sc-394101B sc-394101C sc-394101D | 25 g 100 g 250 g 500 g 1 kg | $54.00 $84.00 $189.00 $204.00 $339.00 | 1 | |
Histidine is an amino acid that chelates zinc ions. Elevated levels of histidine-bound zinc can signal for the increased expression of zinc transporters, potentially enhancing the function of SLC39A11. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 that can influence cellular metabolism and redox states, which can indirectly affect the expression and function of metal ion transporters, including SLC39A11. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression and may upregulate zinc transporters as part of its role in cellular differentiation and growth, possibly affecting SLC39A11 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Can modulate cellular signaling pathways and oxidative stress responses, potentially influencing the expression of zinc transporters like SLC39A11. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol that can activate sirtuins and modulate signaling pathways, which can indirectly lead to the upregulation of metal ion transporters, including SLC39A11. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium influences several signaling pathways and has been shown to affect the expression of various genes, including those involved in metal ion homeostasis, which can impact SLC39A11 expression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a glucocorticoid that can modulate inflammation and cellular stress responses, potentially influencing the expression of zinc transporters like SLC39A11 as part of the cellular adaptation process. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine affects lysosomal function and cellular autophagy, which can lead to changes in the regulation of metal ion transporters as the cell adjusts to altered metal ion storage and distribution, affecting SLC39A11. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that influences cellular signaling and metal ion homeostasis. This can lead to an upregulation of metal ion transporters, including SLC39A11, in a bid to maintain cellular zinc balance. | ||||||