SLC35F1 Activators
SLC35F1 Activators are a specialized set of chemical compounds that indirectly enhance the functional activity of SLC35F1 through a multitude of signaling pathways. Through the modulation of intracellular calcium levels, Verapamil and Ionomycin create a cellular environment conducive to the activation of SLC35F1, while Forskolin and IBMX elevate cAMP levels, indirectly promoting SLC35F1 activity via PKA-mediated phosphorylation events. Phorbol 12-myristate 13-acetate (PMA) and Chlorpromazine, through the activation and modulation of protein kinase C (PKC), respectively, orchestrate a series of phosphorylation reactions that can lead to the enhancement of SLC35F1's transporter function. Capsaicin, by activating TRPV1, also contributes to calcium influx and the subsequent activation of calcium-dependent proteins that can bolster the function of SLC35F1.
Retinoic Acid, Epigallocatechin gallate (EGCG), and Curcumin, though diverse in their mechanisms, converge on the modulation of protein interactions and signaling networks that can enhance SLC35F1 activity. Retinoic Acid achieves this through its receptor-mediated influence on gene expression, EGCG through the inhibition of kinases that may negatively regulate SLC35F1, and Curcumin by affecting multiple signaling pathways. Nicotinamide adenine dinucleotide (NAD+), as a coenzyme, influences cellular metabolism, which can indirectly support the enhancement of SLC35F1's function. These activators, by targeting distinct but interconnected signaling pathways, collectively facilitate an increase in the functional activity of SLC35F1 without necessitating an increase in its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, can enhance the function of SLC35F1 by modulating intracellular calcium levels. Elevated intracellular calcium can affect the transport activity of SLC35F1, which is implicated in the transport of certain molecules across membranes. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can activate PKA. PKA activation can lead to phosphorylation of proteins that interact with SLC35F1 or modulate its activity, thus enhancing the functional performance of SLC35F1 in its role as a transporter. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to phosphorylation of proteins that regulate the activity of SLC35F1. This can enhance the transporter function of SLC35F1 by affecting the membrane environment or the transporter directly. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid can modulate gene expression and protein function through its receptor. By influencing the expression of proteins that interact with SLC35F1, retinoic acid can enhance the functional activity of SLC35F1 indirectly. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is known to inhibit certain protein kinases. By inhibiting these kinases, EGCG may reduce the negative regulation on proteins that are involved in the same pathway as SLC35F1 or directly on SLC35F1, leading to its enhanced activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium can activate calcium-dependent proteins that may regulate the function of SLC35F1, thus potentially enhancing its transporter activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX, a non-specific inhibitor of phosphodiesterases, prevents the breakdown of cAMP. Elevated cAMP levels can lead to activation of PKA, which may phosphorylate and thus enhance the activity of SLC35F1 or its associated regulatory proteins. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to affect multiple signaling pathways, including those that regulate protein function and trafficking. By modulating these pathways, curcumin could enhance the activity of SLC35F1. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1, which can lead to calcium influx and activation of calcium-dependent signaling pathways. These pathways may upregulate the functional activity of SLC35F1 by affecting the transporter directly or the regulatory proteins associated with it. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a coenzyme in redox reactions, NAD+ can influence cellular metabolism and signaling pathways. Through these pathways, NAD+ might enhance the activity of SLC35F1 by modulating its environment or directly influencing its function. | ||||||