SLC35B2 Activators
Chemical activators of SLC35B2 include a variety of compounds that enhance the protein's activity by promoting its proper folding, stabilization, and membrane localization. 4-Phenylbutyric acid and its sodium salt counterpart, Sodium 4-phenylbutyrate, serve as chemical chaperones that can increase the correct folding of SLC35B2, ensuring its optimal conformation and functionality within the endoplasmic reticulum. Similarly, Tauroursodeoxycholic acid, a bile acid derivative, assists in reducing endoplasmic reticulum stress, which in turn supports the activity of properly folded membrane proteins like SLC35B2. Additionally, Curcumin can influence the folding of proteins, activating SLC35B2 by facilitating its appropriate folding and function within the cellular membrane. Betaine, an osmolyte and a methyl donor, contributes to the stabilization of protein structures, which is conducive to the stable expression of SLC35B2 within the membrane.
Compounds such as Dimethyl sulfoxide (DMSO) and Trimethylamine N-oxide (TMAO) are other chemical agents that stabilize protein structures, thus supporting the activity of SLC35B2 by ensuring its proper localization and functionality in the membrane. Brefeldin A disrupts the Golgi apparatus, leading to the redistribution of Golgi proteins to the endoplasmic reticulum, which can inadvertently increase the activity of SLC35B2 through enhanced functional interactions within the ER. Geldanamycin, by binding to heat shock protein 90 (Hsp90), may influence the stabilization and functioning of client proteins, including SLC35B2. Cyclosporin A affects protein folding pathways, promoting the proper folding and function of SLC35B2. Lithium chloride, through its impact on GSK-3 activity, can influence the phosphorylation state and activity of proteins, possibly including SLC35B2, thus activating its function. Lastly, Celecoxib, by binding to and inhibiting carbonic anhydrases, can lead to changes in cellular pH balance, which may activate ion transporters and channels such as SLC35B2 to maintain pH homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-Phenylbutyric acid, through its role as a chemical chaperone, can increase the proper folding and function of proteins, thereby potentially enhancing the activity of SLC35B2 by ensuring its correct conformation and localization in the endoplasmic reticulum. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Similar to 4-Phenylbutyric acid, Sodium 4-phenylbutyrate may enhance the functional activity of SLC35B2 by promoting its proper folding and stabilization, which is necessary for its activity in the cell. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid, as a bile acid derivative, can act as a chemical chaperone to reduce endoplasmic reticulum stress, which can lead to the increased activity of properly folded membrane proteins like SLC35B2. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus structure, which can lead to redistribution of Golgi proteins like SLC35B2 to the endoplasmic reticulum, potentially increasing its activity by enhancing its functional interactions within the ER. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to influence the folding of proteins, and it could activate SLC35B2 by facilitating its proper folding and function within the cellular membrane. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine serves as an osmolyte and a methyl donor in cells, it can stabilize the structure of proteins and thus may enhance the activity of SLC35B2 by promoting its stable expression in the membrane. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is used as a solvent that can also penetrate biological membranes and may stabilize proteins, potentially increasing the activity of SLC35B2 by ensuring its proper membrane localization and function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin binds to heat shock protein 90 (Hsp90) and can modulate its activity; this interaction may result in the stabilization and proper functioning of client proteins like SLC35B2, increasing its activity. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A, known for its role in inhibiting calcineurin, can also influence protein folding pathways in the cell. This action can lead to the activation of SLC35B2 by promoting its proper folding and function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride affects glycogen synthase kinase 3 (GSK-3) activity, and by doing so, it can influence the phosphorylation state and activity of various proteins, potentially including SLC35B2, thereby activating its function. | ||||||