SLC25A48 Inhibitors
SLC25A48 inhibitors are chemical compounds that indirectly influence the activity of the solute carrier family 25 member 48 protein, which is involved in the transport of ADP and ATP across the mitochondrial membrane. These inhibitors exert their effects by targeting various components of the mitochondrial electron transport chain and ATP synthesis machinery, thereby reducing the availability of ATP for SLC25A48 to transport. For instance, certain inhibitors bind directly to the adenine nucleotide translocator, a component closely associated with SLC25A48's function, and prevent the exchange of mitochondrial ADP and ATP. Other inhibitors act on the respiratory chain complexes, such as inhibiting complex I, II, III, or IV, leading to a diminished proton gradient, which is essential for the synthesis of ATP. By disrupting ATP synthesis, these inhibitors indirectly hinder the function of SLC25A48, as it relies on a steady supply of ATP to carry out its transport activities.
Moreover, some inhibitors affect glycolysis and oxidative phosphorylation, processes that supply the necessary ATP for SLC25A48 to function. Inhibitors that uncouple oxidative phosphorylation or inhibit glycolytic enzymes diminish the cytosolic pool of ATP, indirectly affecting SLC25A48 activity. The action of these inhibitors results in a lower concentration gradient of ATP across the mitochondrial membrane, which is crucial for SLC25A48's role in maintaining cellular energy balance. By depleting ATP levels, the transport efficiency of SLC25A48 is compromised, leading to potential disruptions in energy homeostasis and cellular metabolism. Such inhibitors may also affect the mitochondrial membrane potential, further influencing the ability of SLC25A48 to facilitate the exchange of ADP and ATP between the cytosol and the mitochondria.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $418.00 | 10 | |
This compound binds to and inhibits the adenine nucleotide translocator (ANT) in the mitochondria, which is crucial for the transport of ADP and ATP across the inner mitochondrial membrane. By inhibiting ANT, the compound indirectly prevents SLC25A48, a member of the mitochondrial carrier family, from functioning in mitochondrial ADP/ATP transport, leading to a decrease in its activity. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
This compound is a specific inhibitor of complex II in the mitochondrial electron transport chain. By inhibiting this complex, the proton gradient necessary for ATP synthesis is disrupted, which indirectly affects the ADP/ATP exchange process that SLC25A48 is implicated in, leading to reduced activity. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
As an inhibitor of mitochondrial complex I, rotenone reduces the proton gradient required for ATP synthesis. This action indirectly inhibits SLC25A48 by decreasing the availability of ATP for exchange with ADP across the mitochondrial membrane. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
This compound inhibits ATP synthase, thereby reducing ATP production in mitochondria. Reduced ATP levels mean less substrate for SLC25A48 to transport, thus indirectly inhibiting the protein's activity. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
Uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, collapsing the proton gradient and disrupting ATP synthesis, which consequently reduces the ADP/ATP transport activity of SLC25A48. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Inhibits the respiratory chain by binding to complex III, leading to a decrease in ATP synthesis. This reduction in ATP indirectly inhibits the function of SLC25A48 by lowering the translocation of ATP across the mitochondrial membrane. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $56.00 $97.00 | ||
Inhibits glycolysis by reacting with cysteine residues in glycolytic enzymes. By reducing the supply of cytosolic ATP, it indirectly inhibits the function of SLC25A48 because the protein relies on the gradient of ATP and ADP across the mitochondrial membrane. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Targets complex IV of the mitochondrial electron transport chain, leading to decreased ATP production and indirectly inhibiting SLC25A48 by impacting the transport of ATP it mediates. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Inhibits complex III, leading to a reduction in ATP production. This affects SLC25A48 indirectly by decreasing the availability of ATP for mitochondrial transport. | ||||||