SLC25A20 Activators
SLC25A20 Activators comprise a series of chemical compounds that specifically bolster the transport function of SLC25A20, a protein crucial for ferrying fatty acid derivatives into mitochondria for energy production. L-Carnitine, by its very nature, is fundamental to SLC25A20's role, as it binds to acyl groups to form acylcarnitines, which are the direct substrates that SLC25A20 translocates across the mitochondrial membrane. The presence of Palmitoyl-CoA and other acyl-CoAs, as a result of beta-oxidation, creates a high demand for SLC25A20's transport activity, thereby indirectly enhancing its functional role.
Moreover, chemical agents like Peroxisome proliferators and fibrate drugs amplify the beta-oxidation process by upregulating peroxisomal and mitochondrial enzymes, leading to increased production of acyl-CoAs and thereby potentiating SLC25A20's transport activity. Triiodothyronine (T3) serves to increase the transcription of genes involved in fatty acid metabolism, indirectly promoting the activity of SLC25A20 by ensuring a steady supply of substrates. Metformin and Leptin, through the activation of AMPK, enhance fatty acid oxidation, which in turn increases the availability of substrates for SLC25A20, ensuring its heightened functional state. The action of NAD+, pivotal for the dehydrogenase reactions in beta-oxidation, and ANT inhibitors, by modulating the adenine nucleotide levels within the mitochondria, both contribute to creating an environment that necessitates and thus enhances the transport capabilities of SLC25A20.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of long-chain fatty acids into the mitochondria for beta-oxidation. SLC25A20 encodes a carnitine-acylcarnitine translocase which is essential for this process. Thus, L-Carnitine enhances the functional activity of SLC25A20 by providing its substrate. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $33.00 | ||
Peroxisome proliferators such as clofibrate can induce the proliferation of peroxisomes, increasing the beta-oxidation of fatty acids. This can lead to an increased production of acyl-CoA substrates for SLC25A20, thereby enhancing its functional activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is essential for the dehydrogenase steps in beta-oxidation that produce acyl-CoA, the substrate for SLC25A20. Elevated levels of NAD+ can enhance the overall process of beta-oxidation, consequently increasing the activity of SLC25A20. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Leptin can increase fatty acid oxidation through the activation of AMP-activated protein kinase (AMPK) which eventually leads to increased substrate availability for SLC25A20 and thus enhances its activity. | ||||||
Bongkrekic acid | 11076-19-0 | sc-205606 | 100 µg | $400.00 | 10 | |
Inhibitors of the adenine nucleotide translocator (ANT), such as bongkrekic acid, can lead to an accumulation of matrix ATP, which can increase the demand for fatty acid oxidation, indirectly enhancing the activity of SLC25A20. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fibrates activate peroxisome proliferator-activated receptor alpha (PPARα) leading to increased expression of genes involved in fatty acid transport and oxidation, which may enhance the functional activity of SLC25A20 by increasing its substrate availability. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3 increases the expression of genes involved in mitochondrial fatty acid oxidation, which could lead to an increase in the production of acyl-CoA, thus enhancing the functional activity of SLC25A20. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate, a PPAR pan-agonist, can increase the expression of genes involved in fatty acid oxidation, potentially increasing the availability of substrates for SLC25A20 and enhancing its activity. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin activates AMPK which can increase fatty acid oxidation. This process can enhance the activity of SLC25A20 indirectly by increasing the availability of acyl-CoA substrates for transport into the mitochondria. | ||||||