Slc22a22 Activators
Chemical activators of the solute carrier family 22 (organic cation transporter), member 22, engage with the protein in various ways to influence its activity. Amiloride, for instance, inhibits sodium channels, leading to an increase in cellular sodium concentration. This change in ionic balance can activate the transporter by enhancing the electrochemical gradient that drives its function. Similarly, both verapamil and nicardipine, as calcium channel blockers, induce alterations in intracellular calcium levels, which may activate the transporter by modifying the electrochemical gradient across the cell membrane. These alterations in membrane potential and cationic gradient serve as a driving force for the transporter's activity. Quinidine, by blocking potassium channels, can also increase intracellular potassium levels, thus influencing the activity of the transporter by modifying the intracellular ionic environment.
Other chemicals work by affecting intracellular signaling pathways, which in turn may influence the activity of the solute carrier family 22 (organic cation transporter), member 22. Cimetidine and ranitidine, both histamine H2 receptor antagonists, can alter signaling pathways that regulate cation exchange processes within the cell, potentially upregulating the activity of the transporter. Pyrilamine, an antihistamine that blocks histamine H1 receptors, may activate the transporter by altering histamine-mediated cellular responses that influence cation transport mechanisms. Additionally, trimethoprim can create an ionic environment conducive to the transporter's activity by altering ionic balance. Propranolol and clonidine, through their cardiovascular effects, can influence the cationic balance in cardiomyocytes, with potential effects on the transporter. Lastly, metformin's impact on cellular metabolism and ionic homeostasis can activate the transporter by altering cellular energy status and cationic gradients. These chemical activators, through their varied interactions with cellular ionic environments and signaling pathways, can regulate the activity of the solute carrier family 22 (organic cation transporter), member 22.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride acts as an inhibitor of sodium channels, which in turn can increase cellular sodium concentration and thereby activate solute carrier family 22 (organic cation transporter), member 22 by promoting the electrochemical gradient necessary for its function. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, may lead to intracellular calcium variations that could stimulate the activity of solute carrier family 22 (organic cation transporter), member 22 by altering the membrane potential and cationic gradient, which is a driving force for the transporter's function. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine can block potassium channels, potentially increasing intracellular potassium levels, which may activate solute carrier family 22 (organic cation transporter), member 22 by changing the intracellular ionic environment and influencing the transporter's activity. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine acts as a histamine H2 receptor antagonist and can influence intracellular signaling pathways that may upregulate solute carrier family 22 (organic cation transporter), member 22 activity by altering the cation exchange processes in the cell. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $32.00 $81.00 | 5 | |
Nicardipine, another calcium channel blocker, may similarly to verapamil, induce intracellular calcium variations that activate solute carrier family 22 (organic cation transporter), member 22 by modifying the electrochemical gradient across the cell membrane. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $66.00 $158.00 $204.00 $707.00 $3334.00 | 4 | |
Trimethoprim, an antibiotic, can alter bacterial folate metabolism and potentially influence mammalian cells' ionic balance, thus activating solute carrier family 22 (organic cation transporter), member 22 by creating an ionic environment that favors its transporter activity. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a beta-blocker that can affect heart rate and contractility, which may indirectly activate solute carrier family 22 (organic cation transporter), member 22 by influencing the cationic balance in cardiomyocytes and possibly other cell types. | ||||||
Clonidine | 4205-90-7 | sc-501519 | 100 mg | $235.00 | 1 | |
Clonidine, an alpha-2 adrenergic agonist, may activate solute carrier family 22 (organic cation transporter), member 22 through its effects on adrenergic receptors and subsequent changes in intracellular cation concentrations. | ||||||
Isradipine | 75695-93-1 | sc-201467 sc-201467A | 10 mg 50 mg | $86.00 $318.00 | 1 | |
Isradipine is a calcium channel blocker that can lead to alterations in intracellular calcium levels, which may activate solute carrier family 22 (organic cation transporter), member 22 by changing the electrochemical gradient and cationic fluxes across cellular membranes. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin, commonly known as an antidiabetic drug, can influence cellular metabolism and ionic homeostasis, which may activate solute carrier family 22 (organic cation transporter), member 22 by altering cellular energy status and cationic gradients that drive the transporter's activity. | ||||||