SLC22A12 Inhibitors
SLC22A12 inhibitors constitute a distinct chemical class of compounds that target and interact with the SLC22A12 protein, also known as urate transporter 1 (URAT1). SLC22A12 belongs to the SLC22 family of membrane transporters, playing a crucial role in the regulation of uric acid levels in the body. These inhibitors are thoughtfully crafted to establish binding interactions with SLC22A12, potentially influencing its function and its pivotal role in urate reabsorption within the kidneys.
By intervening in the interactions involving SLC22A12, these inhibitors may intricately modulate the transport of uric acid across cell membranes, affecting its disposition and levels in the bloodstream.The development of SLC22A12 inhibitors requires a multifaceted approach, often involving molecular modeling, structural analysis, and comprehensive biochemical assays. Such meticulous measures are essential to ensure the inhibitors' specificity and efficacy in engaging with SLC22A12. Research within this realm aims to deepen the understanding of the intricate molecular mechanisms governing urate transport and its impact on metabolic homeostasis. By delving into the complex interplay surrounding SLC22A12, this research may uncover novel insights into the regulation of uric acid levels and its implications for health and physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is a known inhibitor of URAT1 and has been used for conditions associated with elevated uric acid levels, such as gout. It competitively inhibits the binding of uric acid to SLC22A12. | ||||||
Benzbromarone | 3562-84-3 | sc-233934 sc-233934A | 1 g 5 g | $53.00 $223.00 | ||
Benzbromarone is another URAT1 inhibitor studied in the research of gout. It acts as a competitive inhibitor, preventing the transport of uric acid by SLC22A12. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine, an agent in research used primarily for inflammatory bowel disease, has also been shown to inhibit SLC22A12, resulting in reduced uric acid reabsorption. | ||||||
Pyrazinamide | 98-96-4 | sc-205824 sc-205824A sc-205824B sc-205824C sc-205824D sc-205824E | 10 g 25 g 100 g 250 g 1 kg 5 kg | $49.00 $67.00 $89.00 $151.00 $483.00 $2276.00 | ||
Pyrazinamide, a chemical used in the research of tuberculosis, has been found to inhibit SLC22A12-mediated uric acid transport, potentially contributing to its urate-lowering effect. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol found in green tea, has been shown to inhibit URAT1 activity, thereby reducing uric acid transport by SLC22A12. | ||||||
Diosmin | 520-27-4 | sc-204728 sc-204728A | 5 g 25 g | $58.00 $114.00 | 2 | |
Diosmin, a naturally occurring flavonoid, has been reported to inhibit SLC22A12-mediated uric acid transport, suggesting its potential as a URAT1 inhibitor. | ||||||
Punicalagin | 65995-63-3 | sc-484442 sc-484442A | 1 g 5 g | $200.00 $626.00 | 4 | |
Punicalagin, a polyphenol found in pomegranates, has demonstrated inhibitory effects on SLC22A12, leading to decreased uric acid reabsorption. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid present in various fruits and vegetables, has been reported to inhibit URAT1 activity, suggesting its potential as an SLC22A12 inhibitor. | ||||||