SLC22A12 Antibody (2B5): sc-293405

SLC22A12 Antibody (2B5) is a mouse monoclonal IgG2a kappa light chain antibody that detects SLC22A12 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SLC22A12 antibody (2B5) is available as a non-conjugated format. SLC22A12 protein, also known as RST, OAT4L, or URAT1 (urate transporter-1), is a 553 amino acid multi-pass membrane protein that belongs to the major facilitator superfamily and the organic cation transporter family. SLC22A12 is primarily expressed in the epithelial cells of the proximal tubules in the renal cortex, where SLC22A12 plays a crucial role in the reabsorption of urate, thereby regulating blood urate levels. This function is vital as SLC22A12 helps maintain homeostasis and prevent conditions such as gout, which can arise from elevated urate levels. SLC22A12 facilitates the exchange of urate against organic anions, and defects in the SLC22A12 gene can lead to renal hypouricemia, an inherited disorder characterized by low serum urate levels and high urinary urate excretion due to impaired tubular uric acid transport. Additionally, SLC22A12 contains three consensus sequences for N-glycosylation and two phosphorylation sites for cyclic AMP-dependent protein kinase, which are important for stability and function.

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SLC22A12 Antibody (2B5) References:

1. Molecular identification of a renal urate anion exchanger that regulates blood urate levels.  |  Enomoto, A., et al. 2002. Nature. 417: 447-52. PMID: 12024214
2. Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese.  |  Ichida, K., et al. 2008. Clin Genet. 74: 243-51. PMID: 18492088
3. Urate transport across the apical membrane of renal proximal tubules.  |  Endou, H. and Anzai, N. 2008. Nucleosides Nucleotides Nucleic Acids. 27: 578-84. PMID: 18600508
4. Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.  |  Hamada, T., et al. 2008. Am J Hypertens. 21: 1157-62. PMID: 18670416
5. A novel mutation of SLC22A12 gene causing primary renal hypouricemia in a patient with metabolic syndrome.  |  Lam, CW., et al. 2008. Clin Chim Acta. 398: 157-8. PMID: 18760270
6. T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects.  |  Jang, WC., et al. 2008. Clin Chim Acta. 398: 140-4. PMID: 18824160
7. Prevalence of hypouricaemia and SLC22A12 mutations in healthy Korean subjects.  |  Lee, JH., et al. 2008. Nephrology (Carlton). 13: 661-6. PMID: 19019168
8. High-resolution melting analysis for the rapid detection of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China.  |  Guan, M., et al. 2009. Scand J Rheumatol. 38: 276-81. PMID: 19306160
9. The SLC22A12 gene is associated with gout in Han Chinese and Solomon Islanders.  |  Tu, HP., et al. 2010. Ann Rheum Dis. 69: 1252-4. PMID: 19762362

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SLC22A12 Antibody (2B5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SLC22A12 Antibody (2B5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SLC22A12 Antibody (2B5) Specifications

Alternate Product Name: SLC22A12

Product Clone Name: 2B5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 281-349

Epitope Target: SLC22A12

Epitope Species: human

Product Reactivity/Detection: SLC22A12

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SLC22A12 Antibody (2B5): N/A