SLC17A4 Inhibitors
Chemical inhibitors of SLC17A4 operate by impeding the protein's ability to transport organic anions across cell membranes. Probenecid, for instance, is known for its competitive inhibition at the transport sites of anion transporters, including SLC17A4. It binds to the same sites that the protein's substrates would, thus preventing SLC17A4 from carrying out its transport function. Similar in action, Sulfinpyrazone and Pyrazinoate also obstruct the reabsorption of uric acid by binding to the protein's anion binding sites, thereby impeding the protein's ability to move these molecules across cellular membranes. Benzbromarone and Losartan, although differing in their primary mechanisms, both inhibit SLC17A4 by blocking its specific interaction with urate, rendering the protein unable to fulfil its role in urate transport.
Furthermore, non-steroidal anti-inflammatory drugs (NSAIDs) such as Indomethacin, Ibuprofen, Naproxen, and Phenylbutazone are capable of interfering with SLC17A4's function by disrupting the transport mechanism for organic anions. These NSAIDs have a dual impact on reducing inflammation and inhibiting SLC17A4, though their primary use is not as inhibitors of this protein. Diuretics like Furosemide and Bumetanide, while primarily used to inhibit sodium and chloride reabsorption, also exert an inhibitory influence on SLC17A4. They achieve this by blocking the movement of its organic anion substrates, such as urate, across the cell membrane. Salicylate, as the active metabolite of aspirin, competitively inhibits the transport of urate and other organic anions, disrupting SLC17A4's ability to transport these substrates.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $28.00 $39.00 $100.00 $277.00 | 28 | |
Probenecid is a known inhibitor of various anion transporters. SLC17A4 functions as an organic anion transporter. Probenecid can inhibit the function of SLC17A4 by competitively binding to the transport sites, thus preventing the translocation of substrates across the membrane. | ||||||
Benzbromarone | 3562-84-3 | sc-233934 sc-233934A | 1 g 5 g | $53.00 $223.00 | ||
Benzbromarone is a uricosuric agent that inhibits urate transporters. It can inhibit SLC17A4 by blocking its urate transport function, thereby preventing the reabsorption of uric acid and consequently reducing the substrate availability for SLC17A4-mediated transport. | ||||||
(±)-Sulfinpyrazone | 57-96-5 | sc-202822 sc-202822A | 1 g 5 g | $42.00 $94.00 | 2 | |
Sulfinpyrazone is a compound that inhibits the reabsorption of uric acid by action on renal tubular transport. It inhibits SLC17A4 by occupying the binding sites for organic anions, thus inhibiting the SLC17A4-mediated transport of these molecules across cell membranes. | ||||||
Pyrazinamide | 98-96-4 | sc-205824 sc-205824A sc-205824B sc-205824C sc-205824D sc-205824E | 10 g 25 g 100 g 250 g 1 kg 5 kg | $49.00 $67.00 $89.00 $151.00 $483.00 $2276.00 | ||
Pyrazinoate, a structural analog of uric acid, inhibits the renal reabsorption of uric acid. It can inhibit SLC17A4 by competitively inhibiting the transport of urate and similar organic anions, thereby directly interfering with the protein's transport capabilities. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin, a non-steroidal anti-inflammatory drug, is known to inhibit renal urate transport. It can inhibit SLC17A4 by blocking the transport channels for organic anions, which are substrates for SLC17A4, thereby directly inhibiting its transport function. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $130.00 | 18 | |
Losartan is an angiotensin II receptor antagonist that has been found to inhibit uric acid transporters. As SLC17A4 is involved in urate transport, losartan can inhibit the protein by blocking its interaction with urate, thus inhibiting its transport activity. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen, another non-steroidal anti-inflammatory drug, has effects on renal excretion of uric acid. It can inhibit SLC17A4 activity by interfering with the transport mechanism of organic anions which are substrates for SLC17A4, leading to a decrease in urate reabsorption and inhibition of the protein's function. | ||||||
Naproxen | 22204-53-1 | sc-200506 sc-200506A | 1 g 5 g | $24.00 $41.00 | ||
Naproxen is a non-steroidal anti-inflammatory drug that impacts the renal excretion of uric acid. It inhibits SLC17A4 by interfering with the transport of organic anions, thus inhibiting the protein's functional activity. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
Furosemide is a loop diuretic known to inhibit the reabsorption of sodium and chloride ions, but it also affects uric acid transport. It can inhibit SLC17A4 by blocking the transport of organic anions, which can include urate, thus inhibiting the function of the protein. | ||||||
Phenylbutazone | 50-33-9 | sc-204843 | 5 g | $32.00 | 1 | |
Phenylbutazone is a non-steroidal anti-inflammatory drug that has an inhibitory effect on urate transporters. It can inhibit SLC17A4 by directly interfering with the transport of organic anions, thereby inhibiting the functional activity of the protein. | ||||||