Skint7 Inhibitors
Skint7, a crucial gene involved in the selection and upkeep of intraepithelial T cells, has a predicted function in signaling receptor binding, playing a role in the T cell receptor signaling pathway and the regulation of cytokine production. It is located in the membrane, specifically the external side of the plasma membrane, and is expressed in the skin and thymus.
Inhibition of Skint7 can be achieved through various mechanisms involving real chemical compounds. Direct inhibitors, such as Cyclosporin A and VIVIT, specifically target T cell receptor signaling and NFAT activation, influencing Skint7's role in T cell selection and cytokine regulation. Indirect inhibitors, including Pembrolizumab, Tofacitinib, and Stattic, modulate immune responses and downstream signaling events, impacting Skint7's function. Compounds like FK506, Rapamycin, and LY294002 affect specific pathways, providing diverse strategies for targeted modulation of Skint7. Understanding the detailed interactions between these inhibitors and Skint7 creates the opportunity for discoveries in conditions involving T cell regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporin A, a calcineurin inhibitor, directly disrupts T cell receptor signaling by inhibiting calcineurin, influencing NFAT activation and impacting Skint7's role in T cell selection and cytokine regulation. | ||||||
NFAT Inhibitor | 249537-73-3 | sc-507480 | 1 mg | $620.00 | ||
VIVIT, an NFAT inhibitor, directly targets NFAT activation, affecting Skint7's involvement in the T cell receptor signaling pathway and regulating cytokine production. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Stattic, a STAT3 inhibitor, directly affects the regulation of cytokine production by inhibiting STAT3 activation, influencing Skint7's involvement in the control of cytokine production. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib, a Src inhibitor, indirectly influences Skint7 by modulating T cell receptor signaling through the inhibition of Src kinases, impacting downstream events related to Skint7's function. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $76.00 $148.00 | 9 | |
FK506, a calcineurin-NFAT pathway modulator, directly modulates NFAT activation, affecting Skint7's role in T cell receptor signaling and the regulation of cytokine production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly affects Skint7 by modulating the T cell receptor signaling pathway through inhibition of mTOR, impacting downstream events related to Skint7's function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K inhibitor, directly influences the T cell receptor signaling pathway by inhibiting PI3K, altering downstream events associated with Skint7's role in T cell activation and cytokine regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126, a MAPK pathway inhibitor, indirectly influences Skint7 by modulating T cell receptor signaling, inhibiting the MAPK pathway, and impacting downstream events associated with Skint7's function. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082, an NF-κB inhibitor, directly affects the regulation of cytokine production by inhibiting NF-κB activation, influencing Skint7's involvement in the control of cytokine production. | ||||||