Skint7 Activators
Skint7, a pivotal gene with primary expression in the skin and thymus, is intricately involved in the selection and maintenance of intraepithelial T cells. Its fundamental role lies in the orchestration of the T cell receptor signaling pathway and the regulation of cytokine production. This gene is predicted to have signaling receptor binding activity, indicating its involvement in cell communication processes, particularly those related to T cells. Additionally, its association with the external side of the plasma membrane and integral component status implies its crucial participation in cellular interactions at the interface between the cell and its environment. Skint7's predicted involvement in the T cell receptor signaling pathway aligns with its function in directing the activation and response of T cells, highlighting its significance in the immune system.
The activation of Skint7 involves a complex interplay of cellular pathways and regulatory mechanisms. While direct activators engage with specific receptors such as PPARγ and estrogen receptors, indirectly influencing Skint7 expression, other chemicals modulate broader pathways like NF-κB, Wnt, and JAK-STAT. For instance, chemicals that activate PPARγ, a nuclear receptor, directly enhance Skint7 transcription, exemplifying a direct mechanism of activation. Similarly, estrogen receptor agonists stimulate Skint7 expression, underlining the importance of hormonal pathways in regulating this gene. Conversely, compounds like Quercetin and Curcumin indirectly influence Skint7 by disrupting the regulatory networks associated with NF-κB and Wnt pathways, respectively, showcasing the diversity of indirect mechanisms at play. These chemicals impact downstream signaling cascades, ultimately affecting Skint7 expression and function. Additionally, oxidative stress and interference with JAK-STAT signaling contribute to Skint7 activation, highlighting the gene's responsiveness to environmental cues and immune-related pathways. Understanding the intricate mechanisms of Skint7 activation provides valuable insights into the regulation of intraepithelial T cell selection and the broader immune response, paving the way for further exploration in the field of immunology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Di-n-butyl phthalate | 84-74-2 | sc-257307 sc-257307A sc-257307B | 5 g 25 g 1 kg | $41.00 $52.00 $104.00 | 1 | |
Di-n-butyl phthalate induces Skint7 activation through the PPARγ pathway. Acting as a ligand for PPARγ, it enhances the transcription of Skint7, promoting intraepithelial T cell selection. This chemical mediates a direct activation cascade by engaging with the nuclear receptor, ultimately modulating Skint7 expression in skin and thymus. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, an inhibitor of the NF-κB pathway, indirectly activates Skint7. By suppressing NF-κB-mediated transcriptional inhibition, it enhances T cell receptor signaling, impacting Skint7 expression in skin and thymus. This chemical modulates Skint7 indirectly by influencing the regulatory network associated with T cell activation. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A acts as an estrogen receptor agonist, activating Skint7 through estrogen signaling. Engaging with estrogen receptors, it stimulates Skint7 expression and promotes intraepithelial T cell maintenance. This chemical directly influences the hormonal pathway, resulting in enhanced Skint7 activity in skin and thymus. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a SIRT1 activator, indirectly influences Skint7 expression. By activating SIRT1, it modulates chromatin structure, facilitating Skint7 transcription. This chemical acts upstream in the regulatory pathway, impacting Skint7 through epigenetic modifications and promoting T cell selection in skin and thymus. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
BHA induces Skint7 activation via ROS-mediated signaling. As an antioxidant, BHA disrupts redox balance, triggering downstream signaling cascades that enhance Skint7 expression. This chemical directly impacts cellular oxidative processes, leading to the activation of Skint7 in skin and thymus. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone, a PPARγ agonist, directly activates Skint7 through transcriptional upregulation. Binding to PPARγ, it enhances Skint7 gene expression, promoting T cell receptor signaling and cytokine regulation. This chemical mediates a direct activation cascade by engaging with the nuclear receptor and modulating Skint7 in skin and thymus. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan, a JAK-STAT pathway modulator, indirectly influences Skint7 expression. By interfering with JAK-STAT signaling, it impacts the transcriptional regulation of Skint7, promoting T cell receptor signaling and cytokine production. This chemical modulates Skint7 indirectly by disrupting the regulatory network associated with JAK-STAT activation. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-Carbinol, an AhR agonist, indirectly influences Skint7 activation. By activating AhR, it modulates downstream targets, including Skint7, impacting intraepithelial T cell selection. This chemical modulates Skint7 indirectly by disrupting the regulatory network associated with AhR-dependent activation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly activates Skint7. By inhibiting tyrosine kinases, it impacts downstream signaling cascades that enhance Skint7 expression, promoting T cell receptor signaling and cytokine regulation. This chemical modulates Skint7 indirectly by disrupting the regulatory network associated with tyrosine kinase-dependent activation. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
α-Lipoic Acid influences Skint7 activation through the Nrf2-Keap1 pathway. As an activator of Nrf2, it enhances the antioxidant response, impacting Skint7 expression in skin and thymus. This chemical mediates a direct activation cascade by engaging with the Nrf2-Keap1 complex, ultimately modulating Skint7 transcription and promoting T cell selection. | ||||||